CAREER: NEW WATER-SOLUBLE LIGANDS AND TRANSITION METAL COMPLEXES FOR ENZYME MODELING AND CATALYSIS

职业：用于酶建模和催化的新型水溶性配体和过渡金属配合物

• 批准号: 0846383
• 负责人: Elizabeth Papish
• 金额: $ 57万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0846383&HistoricalAwards=false
• 关键词: CAREER; NEW; WATER; SOLUBLE; LIGANDS

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Papish at Drexel University to synthesize and study new ligands and complexes; the goal is to mimic the structure and function of important metalloenzymes. In particular, the Papish group is interested in modeling phosphotriesterase (PTE) because PTE catalyzes the hydrolysis of both pesticides and nerve gases. New ligands will be designed to mimic the secondary coordination sphere and provide water-solubility, properties that should lead to fast catalysis of important hydrolysis reactions. The scope of potential research applications is large and includes modeling various esterases, carbonic anhydrase and oxygenases. Model complexes could provide catalysts for green chemistry applications, including the breakdown of environmental toxins, the harnessing of oxygen as an abundant and environmentally benign oxidant, and the development of a class of ligands that is compatible with water as an alternative to the use of organic solvents. This research project will be used as a means of educating and motivating high school, undergraduate and graduate students to study science by directly involving students in the research. To illustrate that science and research are viable career paths for currently underrepresented groups, a workshop on 'Careers in Chemistry' that features women and minority chemists will be established. This workshop will create an informal network of peer and professional role models for students; members of this network can serve as mentors. In addition, they will describe the series of decisions that led them to become successful scientists.

该职业生物，生物促和有机化化学计划的职业奖支持Drexel University Papish教授的工作，以合成和研究新的配体和建筑群；目标是模仿重要的金属酶的结构和功能。 特别是，教皇组对对磷酸三酯酶（PTE）进行建模感兴趣，因为PTE催化了农药和神经气体的水解。 新的配体将被设计为模仿二次配位球并提供水溶性，这些特性应导致重要的水解反应快速催化。 潜在研究应用的范围很大，包括对各种酯酶，碳赤霉酶和氧酶进行建模。 模型复合物可以为绿色化学应用提供催化剂，包括环境毒素的分解，将氧气作为丰富且环境良性的氧化剂的利用以及与水兼容的一类配体的发展，以替代有机溶剂的使用。该研究项目将被用作教育和激励高中，本科生和研究生通过直接参与研究来学习科学的一种手段。 为了说明科学和研究是当前代表性不足的群体的可行职业道路，将建立有关妇女和少数化学家的“化学职业”研讨会。 该研讨会将为学生创建一个非正式的同伴和专业榜样网络；该网络的成员可以担任导师。此外，他们将描述一系列决定，使他们成为成功的科学家。