PFI-TT: Increasing commercial potential of deep skin imaging using OCT.

PFI-TT：增加使用 OCT 进行深层皮肤成像的商业潜力。

• 批准号: 1827560
• 负责人: Adam Wax
• 金额: $ 20万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827560&HistoricalAwards=false
• 关键词: PFI; TT; Increasing; commercial; potential

The broader impact/commercial potential of this PFI project is to improve skin imaging to see deep enough below the tissue surface that they are useful for dermatologists and surgeons. The technique, called optical coherence tomography or OCT, can non-invasively image tissues with near cellular resolution and identify changes in structure due to disease or injury. While OCT has shown great capabilities for imaging the retina, the approach offers limited depth penetration which has prevented success in other tissues. We have developed a new approach for OCT, under NSF support (CBET 1133222), that significantly extends its depth penetration. Increasing depth penetration will open up new applications, particular for diagnosing skin disease. We expect this project to help justify commercialization by our partner company by showing that the technology can image skin in a format that is compatible with medical practice of dermatologists and surgeons. This proposal seeks to build and test a prototype system with enough scanning range to be useful to medicine. The technology will be tested and validated with skin imaging in animal models. By increasing access to better biomedical imaging technology, we will advance the health and welfare of the American public.The proposed project will advance a new imaging modality, dual axis OCT, towards a practical implementation for imaging skin. The proposal builds on NSF supported work that demonstrated the principle of extended depth imaging in OCT. Currently, OCT is not widely used for skin imaging due to limited penetration depth and an inability to evaluate large enough tissue areas. The proposed work will address this shortcoming. First, we will build a new scanning system that will validate that the approach can be used to examine larger tissue areas yet penetrate deeply into biological tissues such as animal skin. Second, we will implement a new dynamic focusing approach that will enable commercial success by making allowing physicians to image tissues at several millimeters below the tissue surface without repositioning the device. Finally, this proposal will demonstrate the medical applicability of the approach by imaging in vivo animal tissues.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 PFI 项目更广泛的影响/商业潜力是改善皮肤成像，以查看组织表面以下足够深处的情况，这对皮肤科医生和外科医生来说非常有用。 该技术称为光学相干断层扫描（OCT），可以以接近细胞分辨率的方式对组织进行非侵入性成像，并识别由于疾病或损伤而导致的结构变化。虽然 OCT 已显示出对视网膜成像的强大能力，但该方法的穿透深度有限，这阻碍了在其他组织中的成功。在 NSF 的支持下 (CBET 1133222)，我们开发了一种新的 OCT 方法，可显着扩展其深度渗透。 增加渗透深度将开辟新的应用，特别是在诊断皮肤病方面。我们希望该项目能够证明该技术可以以与皮肤科医生和外科医生的医疗实践兼容的格式对皮肤进行成像，从而帮助我们的合作伙伴公司证明其商业化的合理性。 该提案旨在构建和测试具有足够扫描范围的原型系统，以用于医学。 该技术将通过动物模型的皮肤成像进行测试和验证。通过增加获得更好的生物医学成像技术的机会，我们将促进美国公众的健康和福利。拟议的项目将推进一种新的成像模式——双轴 OCT，以实现皮肤成像的实际应用。该提案建立在 NSF 支持的工作之上，该工作演示了 OCT 中扩展深度成像的原理。目前，由于穿透深度有限且无法评估足够大的组织区域，OCT 并未广泛用于皮肤成像。拟议的工作将解决这一缺点。首先，我们将建立一个新的扫描系统，以验证该方法可用于检查更大的组织区域，并能深入渗透到动物皮肤等生物组织中。其次，我们将实施一种新的动态聚焦方法，使医生无需重新定位设备即可对组织表面以下几毫米的组织进行成像，从而实现商业成功。 最后，该提案将通过对动物组织进行体内成像来证明该方法的医学适用性。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Origin of improved depth penetration in dual‐axis optical coherence tomography: a Monte Carlo study

双轴光学相干断层扫描深度穿透改进的起源：蒙特卡罗研究

• DOI: 10.1002/jbio.201800383
• 发表时间: 2019
• 期刊: Journal of Biophotonics
• 影响因子: 2.8
• 作者: Zhao, Yang;Chu, Kengyeh K.;Jelly, Evan T.;Wax, Adam
• 通讯作者: Wax, Adam

Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model.

• DOI: 10.1364/ol.44.005590
• 发表时间: 2019-11-15
• 期刊: Optics letters
• 影响因子: 3.6
• 作者: Jelly ET;Steelman ZA;Wax A
• 通讯作者: Wax A