PFI-TT: Increasing commercial potential of deep skin imaging using OCT.

PFI-TT：增加使用 OCT 进行深层皮肤成像的商业潜力。

• 批准号: 1827560
• 负责人: Adam Wax
• 金额: $ 20万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827560&HistoricalAwards=false
• 关键词: PFI; TT; Increasing; commercial; potential

The broader impact/commercial potential of this PFI project is to improve skin imaging to see deep enough below the tissue surface that they are useful for dermatologists and surgeons. The technique, called optical coherence tomography or OCT, can non-invasively image tissues with near cellular resolution and identify changes in structure due to disease or injury. While OCT has shown great capabilities for imaging the retina, the approach offers limited depth penetration which has prevented success in other tissues. We have developed a new approach for OCT, under NSF support (CBET 1133222), that significantly extends its depth penetration. Increasing depth penetration will open up new applications, particular for diagnosing skin disease. We expect this project to help justify commercialization by our partner company by showing that the technology can image skin in a format that is compatible with medical practice of dermatologists and surgeons. This proposal seeks to build and test a prototype system with enough scanning range to be useful to medicine. The technology will be tested and validated with skin imaging in animal models. By increasing access to better biomedical imaging technology, we will advance the health and welfare of the American public.The proposed project will advance a new imaging modality, dual axis OCT, towards a practical implementation for imaging skin. The proposal builds on NSF supported work that demonstrated the principle of extended depth imaging in OCT. Currently, OCT is not widely used for skin imaging due to limited penetration depth and an inability to evaluate large enough tissue areas. The proposed work will address this shortcoming. First, we will build a new scanning system that will validate that the approach can be used to examine larger tissue areas yet penetrate deeply into biological tissues such as animal skin. Second, we will implement a new dynamic focusing approach that will enable commercial success by making allowing physicians to image tissues at several millimeters below the tissue surface without repositioning the device. Finally, this proposal will demonstrate the medical applicability of the approach by imaging in vivo animal tissues.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该PFI项目的更广泛的影响/商业潜力是改善皮肤成像，以在组织表面下方看到足够深的皮肤成像，以使其对皮肤科医生和外科医生有用。 该技术称为光学相干断层扫描或OCT，可以非侵入性地图像具有接近细胞的分辨率的组织，并确定由于疾病或损伤而导致的结构变化。虽然OCT表现出很大的能力来对视网膜进行成像，但该方法提供了有限的深度穿透性，从而阻止了其他组织的成功。我们已经在NSF支持（CBET 113222）下开发了一种新的OCT方法，该方法大大扩展了其深度渗透。 深度渗透的增加将为诊断皮肤疾病的诊断提供新的应用。我们希望该项目通过表明该技术可以以与皮肤科医生和外科医生的医学实践相兼容的形象形象的皮肤来帮助我们的合作伙伴公司的商业化合理。 该建议旨在建立和测试具有足够扫描范围的原型系统，可对医学有用。 该技术将在动物模型中对皮肤成像进行测试和验证。通过增加获得更好的生物医学成像技术的访问，我们将提高美国公众的健康和福利。拟议的项目将推进新的成像方式，即Dual Axis OCT，朝着对皮肤进行成像的实践实现。该提案建立在NSF支持的工作的基础上，该工作证明了10月的扩展深度成像原则。目前，由于穿透深度有限，无法评估足够大的组织区域，因此OCT并未广泛用于皮肤成像。拟议的工作将解决这一缺点。首先，我们将建立一个新的扫描系统，该系统将验证该方法可用于检查较大的组织区域，但深入渗透到诸如动物皮肤等生物组织中。其次，我们将实施一种新的动态聚焦方法，该方法将通过使医生能够在组织表面以下几毫米的组织不重新定位设备的情况下对组织进行成像，从而实现商业成功。 最后，该提案将通过对体内动物组织进行成像来证明该方法的医学适用性。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响评估标准通过评估来支持的。

项目成果

Origin of improved depth penetration in dual‐axis optical coherence tomography: a Monte Carlo study

双轴光学相干断层扫描深度穿透改进的起源：蒙特卡罗研究

• DOI: 10.1002/jbio.201800383
• 发表时间: 2019
• 期刊: Journal of Biophotonics
• 影响因子: 2.8
• 作者: Zhao, Yang;Chu, Kengyeh K.;Jelly, Evan T.;Wax, Adam
• 通讯作者: Wax, Adam

Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model.

• DOI: 10.1364/ol.44.005590
• 发表时间: 2019-11-15
• 期刊: Optics letters
• 影响因子: 3.6
• 作者: Jelly ET;Steelman ZA;Wax A
• 通讯作者: Wax A