Increased Depth Penetration in Coherence Imaging Using Multiply Scattered Light

使用多重散射光增强相干成像的深度穿透力

• 批准号: 1133222
• 负责人: Adam Wax
• 金额: $ 30万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1133222&HistoricalAwards=false
• 关键词: Increased; Depth; Penetration; Coherence; Imaging

1133222WaxThe PI proposes to develop ms/LCI (multiple scattering/low coherence interferometry) to image through thick tissues with multiply scattered light. The specific tasks proposed are: 1. Instrument development:The system will be modified to enable optical scanning and multispectral interferometric imaging. Optical scanning will improve the speed of acquiring 2D images while inclusion of multiple illumination wavelengths will allow recovery of important biochemical information such as hemoglobin concentration and oxygenation. 2. Theoretical modeling:To better understand the mechanisms of imaging contrast in this approach the PI will take a dual pronged effort to model the light propagation. An analytical form is presented which is based on a random walk formalism that will be used to evaluate this imaging modality. To validate this model, they will also use Monte Carlo modeling as well as comparing to experimental results. 3. Demonstrate imaging of hemoglobin distribution in thick tissues.To demonstrate the utility of the method, they will image hemoglobin distribution through thick (~1 cm) tissues. Samples will include tissue phantoms, designed to validate the method, and ex vivo animal tissues, such as muscle and fat as would be encountered in breast imaging and retinal samples as would be used in OCT ophthalmic imaging, where penetration to the choroid has remained a challenge. The proposed research will advance a novel imaging modality with unique potential to extend imaging depth. In addition, new multispectral interferometry instrumentation will advance optical engineering while the proposed random walk model will advance understanding of light propagation in tissues.

1133222WaxPI 提议开发 ms/LCI（多重散射/低相干干涉测量法），利用多重散射光对厚组织进行成像。提出的具体任务是： 1.仪器开发：将修改系统以实现光学扫描和多光谱干涉成像。光学扫描将提高采集 2D 图像的速度，同时包含多个照明波长将允许恢复重要的生化信息，例如血红蛋白浓度和氧合。 2. 理论建模：为了更好地理解这种方法中成像对比度的机制，PI 将采取双管齐下的努力来模拟光传播。提出了一种基于随机游走形式的分析形式，用于评估这种成像模式。为了验证该模型，他们还将使用蒙特卡罗建模并与实验结果进行比较。 3. 演示厚组织中血红蛋白分布的成像。为了演示该方法的实用性，他们将对厚组织（~1 cm）的血红蛋白分布进行成像。样品将包括旨在验证该方法的组织模型，以及离体动物组织，例如乳房成像中会遇到的肌肉和脂肪，以及 OCT 眼科成像中使用的视网膜样品，其中对脉络膜的渗透仍然是一个难题。挑战。拟议的研究将推进一种新颖的成像方式，具有扩展成像深度的独特潜力。此外，新的多光谱干涉测量仪器将推动光学工程的发展，而提出的随机游走模型将促进对组织中光传播的理解。