Near Threshold Excited State Dynamics in Nucleobases and Related Compounds

核碱基和相关化合物的近阈值激发态动力学

基本信息

批准号：
1800283
负责人：
Mattanjah de Vries
金额：
$ 54.49万
依托单位：
University of California-Santa Barbara
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2022-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1800283&HistoricalAwards=false
关键词：
Near Threshold Excited State Dynamics

项目摘要

In this project, funded by the Chemical Structure Dynamics and Mechanism (CSDM-A) program of the Chemistry Division, Prof. de Vries at the University of California Santa Barbara will study how isolated DNA bases respond to ultraviolet (UV) light. Understanding the response of DNA bases to UV radiation is critical for both practical and fundamental reasons. Nucleobase photochemistry following UV absorption constitutes a fundamental step in radiation induced DNA damage. The extremely efficient response of the nucleobases to absorption of ultraviolet light is often described as nature's strategy to protect the building blocks of life against UV photodamage. UV photo-selection may have played a key role in prebiotic chemistry on an early earth. These same processes also find applications in a variety of modern materials. This project will focus on gas phase spectroscopy of nucleobases and their clusters in the picosecond time domain and close to the threshold for absorption. Experiments will study the excited state processes with the isomer specificity afforded by double resonant spectroscopy in the gas phase and in the sub-nanosecond time domain. Collaboration with computational chemists will provide comparison of the results with quantum chemical modeling. Choosing low energy excitation wavelengths will make the work most sensitive to the details of the relaxation processes. This approach will make it possible to directly investigate the key mechanisms of the response of nucleobases to UV irradiation so this research will contribute to the most basic understanding of fundamental processes that govern the molecular building blocks of life. These topics, in combination with cutting-edge laser and computational techniques, lend themselves extraordinary well to outreach activities that will be based in this work, which also provides for the training of both undergraduate and graduate students in the design and construction of advanced experimental instrumentation, complex computer simulation, and conducting fundamental research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个项目中，由化学部化学结构动力学和机理（CSDM-A）项目资助，加州大学圣塔芭芭拉分校的de Vries教授将研究分离的DNA碱基如何响应紫外线（UV）。出于实际和根本原因，了解 DNA 碱基对紫外线辐射的反应至关重要。紫外线吸收后的核碱基光化学构成了辐射诱导 DNA 损伤的基本步骤。核碱基对紫外线吸收的极其有效的反应通常被描述为大自然保护生命构件免受紫外线光损伤的策略。紫外线光选择可能在早期地球的生命起源化学中发挥了关键作用。这些相同的工艺也适用于各种现代材料。该项目将重点关注皮秒时域和接近吸收阈值的核碱基及其簇的气相光谱。实验将研究气相和亚纳秒时域中双共振光谱提供的具有异构体特异性的激发态过程。与计算化学家的合作将提供结果与量子化学模型的比较。选择低能量激发波长将使工作对弛豫过程的细节最敏感。这种方法将使直接研究核碱基对紫外线照射响应的关键机制成为可能，因此这项研究将有助于对控制生命分子构建模块的基本过程的最基本的理解。这些主题与尖端激光和计算技术相结合，非常适合基于这项工作的外展活动，这也为本科生和研究生提供了设计和建造先进实验仪器的培训、复杂的计算机模拟以及进行基础研究。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A compact and cost-effective laser desorption source for molecular beam generation: comparison with simulations

用于分子束生成的紧凑且经济有效的激光解吸源：与模拟的比较

DOI：
10.1088/1361-6455/ac259b
发表时间：
2021-09
期刊：
Molecular and Optical Physics
影响因子：
0
作者：
Shachar, Afik;Kallos, Itai;de Vries, Mattanjah S;Bar, Ilana
通讯作者：
Bar, Ilana

Understanding How a New Hachimoji Nucleobase Alters Photodynamics of Genetic Building Blocks †

了解新的八字核碱基如何改变遗传构件的光动力学 –

DOI：
10.1111/php.13709
发表时间：
2023-03
期刊：
Photochemistry and Photobiology
影响因子：
3.3
作者：
de Vries; Mattanjah S.
通讯作者：
Mattanjah S.

Excited state intramolecular proton transfer in hydroxyanthraquinones: Toward predicting fading of organic red colorants in art

羟基蒽醌中的激发态分子内质子转移：预测艺术中有机红色着色剂的褪色

DOI：
10.1126/sciadv.aaw5227
发表时间：
2019-09-01
期刊：
Science Advances
影响因子：
13.6
作者：
J. Berenbeim;S. Boldissar;Shawn C. Owens;M. Haggmark;G. Gate;F. Siouri;T. Cohen;Michał F. Rode;C. S. Patterson;M. S. D. Vries
通讯作者：
M. S. D. Vries

Revealing the Structure and Noncovalent Interactions of Isolated Molecules by Laser-Desorption/Ionization-Loss Stimulated Raman Spectroscopy and Quantum Calculations

通过激光解吸/电离损失受激拉曼光谱和量子计算揭示孤立分子的结构和非共价相互作用

DOI：
10.1021/acs.jpclett.1c03336
发表时间：
2021-11
期刊：
The Journal of Physical Chemistry Letters
影响因子：
0
作者：
Shachar, Afik;Kallos, Itai;de Vries, Mattanjah S.;Bar, Ilana
通讯作者：
Bar, Ilana

Photodynamics of alternative DNA base isoguanine

替代DNA碱基异鸟嘌呤的光动力学

DOI：
10.1039/c9cp01622h
发表时间：
2019-01
期刊：
Physical Chemistry Chemical Physics
影响因子：
3.3
作者：
Gate, Gregory;Szabla, Rafał;Haggmark, Michael R.;Šponer, Jiří;Sobolewski, Andrzej L.;de Vries, Mattanjah S.
通讯作者：
de Vries, Mattanjah S.