PILOT EXPLORATORY STUDIES CORE

试点探索性研究核心

• 批准号: 7898713
• 负责人: GAIL A GREENDALE
• 金额: $ 24.62万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7898713
• 关键词: Advisory Committees; Age; American; Amyloid deposition; Anemia due to Chronic Disorder; Area; Award; Basic Science; Biomechanics; Biomedical Research; Brain; Brain-Derived Neurotrophic Factor; Cancer Survivor; Charge; Clinical; Clinical Research; Clinical Sciences; Cognitive; Collaborations; Communication; Discipline of obstetrics; Doctor of Philosophy; Fatigue; Fellowship; Fostering; Funding; Future; Geriatrics; Gynecology; Health; Homeostasis; Hyperkyphosis; Impaired cognition; Individual; Insulin; Internal Medicine; Intervention; Iron; Laboratories; Lead; Leadership; Long-Term Care; Mediator of activation protein; Medical; Medicine; Menopause; Modification; Monitor; Osteoporosis; Participant; Pathology; Pattern; Persons; Pharmaceutical Preparations; Physical Function; Process; Progress Reports; Psychologist; Recording of previous events; Request for Applications; Request for Proposals; Research; Research Personnel; Research Training; Science; Scientist; Series; Signal Pathway; Staging; Testing; Upper Extremity; Upper arm; Yoga; age related; base; clinical epidemiology; design; falls; hepcidin; immunosenescence; innovation; kinematics; malignant breast neoplasm; medical schools; meetings; middle age; mimetics; multidisciplinary; novel; peptide hormone; prevent; professor; programs; research study; small molecule; successful intervention; tau Proteins

Overview. According to the RFA, the Pilot/Exploratory Studies Core (P/EC) is charged with fostering the conduct of studies "...to acquire information needed to select and design future crucial studies in the OAIC area of focus." To meet this mandate, the UCLA P/EC is will promote innovative basic and clinical research, conducted by collaborating teams of junior and senior investigators, that falls within the UCLA OAlC's research theme and that will serve as the basis for additional, important research studies. Leadership. Gail A. Greendale, MD, Professor of Medicine/Geriatrics, and an expert in the areas of menopause, osteoporosis, & physical functioning will lead the interdisciplinary team. The P/EC co-leader will be Rita Effros, PhD, Professor of Pathology/Laboratory Medicine and a basic scientist who studies immunosenescence. Sandra Simmons, PhD, Asst. Professor of Medicine/Geriatrics, and a psychologist specializing in clinical interventions for residents in long-term care, will be the assistant leader. Pilot Processes. There will be clear processes for selection of pilots, monitoring progress of pilots, and developing pilots into independently funded research awards. Selection will consist of a staged process that includes a request for proposals; request for full applications from meritorious applicants; and a series of reviews culminating with final selection by the Executive Committee, External Advisory Committee and External Selection Panel. Each pilot Will be monitored by a P/EC liaison; monitoring will include monthly progress reports; quarterly meetings with the liaison; annual presentation at the Geriatrics Research & OAIC Seminar Series; and annual presentation to the External Advisors. Pilots. Four pilots are proposed. In brief, these are: Hepcidin antagonists to treat anemia of inflammation. The pilot PI discovered the peptide hormone, hepcidin, a regulator of iron homeostasis and the main mediator of anemia of inflammation. Using hepcidin as a target, this study aims to identify compounds for the treatment of anemia of inflammation. Novel drugs for age-related cognitive and svnaptic deficits. In an effort to discover ways to prevent cognitive decline, this pilot will evaluate the effects of 2 small molecule mimetics of insulin and brain-derived neurotrophic factor on key signaling pathways, on tau modification and accumulation, and on amyloid deposition in the brain. Upper-extremity function following Yoga for hvperkvphosis. Using novel upper extremity biomechanical assessments, the PI will quantify baseline and change in scapulohumeral kinematic patterns during functional tasks among participants in a funded RCT of Yoga for hyperkyphosis. Yoga for older breast cancer survivors (BCS) with fatigue. In a single armed pilot, the PI found that lyengar yoga ameliorated persistent fatigue among middle-aged BCS. She proposes an RCT to develop and test a modified, age-appropriate lyengar yoga program for older BCS with fatigue.

概述。根据RFA，试点/探索性研究核心（P/EC）被指控促进 进行研究“ ...获取在OAIC中选择和设计未来关键研究所需的信息 为了满足这一任务，UCLA P/EC将促进创新的基础和临床研究， 由Junior和高级调查员的合作团队进行的，属于UCLA OALC的 研究主题，这将是其他重要研究的基础。 领导。医学/老年医学教授Gail A. Greendale医学博士，领域的专家 更年期，骨质疏松症和身体功能将领导跨学科团队。 P/EC共同领导者将 是丽塔·埃弗罗斯（Rita Effros）博士，病理学/实验室医学教授和研究的基础科学家 免疫衰老。桑德拉·西蒙斯（Sandra Simmons）博士，助理。医学/老年医学教授和心理学家 专门研究长期护理中居民的临床干预措施将是助理领导者。 试点过程。将有明确的过程来选择飞行员，监视飞行员的进度以及 将飞行员发展为独立资助的研究奖。选择将包括一个分阶段的过程 包括提案请求；请求有功申请人的全部申请；和一系列 审查执行委员会，外部咨询委员会和 外部选择面板。每个飞行员将由P/EC联络人监视；监视将包括每月 进度报告；与联络人的季度会议；在老年研究与OAIC的年度演讲 研讨会系列；以及向外部顾问的年度介绍。 飞行员。提出了四个飞行员。简而言之，这些是：肝素拮抗剂治疗炎症贫血。 飞行员PI发现了肽激素，肝素，铁稳态的调节剂和主要 炎症贫血的介体。本研究以肝素为靶标，旨在识别 治疗炎症贫血。与年龄有关的认知和svnaptic缺陷的新型药物。努力 为了发现预防认知能力下降的方法，该飞行员将评估2个小分子模拟物的影响 胰岛素和脑衍生的神经营养因子在关键信号通路，TAU修饰和 积累，以及大脑中的淀粉样沉积。瑜伽之后的高级功能 hvperkvphphosis。使用新型的上肢生物力学评估，PI将量化基线和 在资助的RCT中，参与者在功能任务中的肩humeral运动学模式的变化 瑜伽高温。老年乳腺癌幸存者（BCS）的瑜伽患有疲劳。在一个武装飞行员中， PI发现Lyengar瑜伽在中年BC中改善了持续的疲劳。她提出了一个 RCT开发和测试针对患有疲劳的老年BC的改良，适合年龄的Lyengar瑜伽计划。