REU Site: Undergraduate Research Experience in Biomedical Translational Science and Technology Development

REU 网站：生物医学转化科学与技术开发的本科生研究经验

• 批准号: 1757846
• 负责人: Kaiming Ye
• 金额: $ 36.17万
• 依托单位: SUNY at Binghamton
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1757846&HistoricalAwards=false
• 关键词: REU; Site; Undergraduate; Research; Experience

The rapid expansion of biomedical science has resulted in a short supply of biomedical scientists and engineers at all career levels, presenting an immediate need to educate and train more young people in the skills and knowledge required for biomedical science and engineering. To meet this demand, Binghamton University (BU-SUNY) will host a 10-week summer REU program to train 10 undergraduate students per year in translational biomedical science and engineering. The program will offer undergraduates intensive multidisciplinary hands-on research and professional development training in integrated biomedical translational science and technology development. The program is anticipated to develop a leadership pipeline helping students advance in either their graduate studies or career and professional training in these fields. The teaming of biomedical scientists with engineers has led to the development of this novel and unique REU program. The fourteen participating faculty members combined have trained nearly 684 REU students, leading to 80 peer-reviewed research articles co-authored by undergraduates. BU's strong commitment to undergraduate education and research will ensure the success of the proposed REU program. The broad and cohesive research interests of faculty mentors involved in this program allow for designing and implementing a vigorous summer REU program to offer T-shaped professional training opportunities to undergraduates. Efforts will be made to recruit students from underrepresented groups, such as women, minority students and students from undergraduate institutions and community colleges where undergraduate research training is limited. The outcome of the REU program will be disseminated at national conferences and published in peer-reviewed journals.The REU program will provide students with opportunities to learn how engineering principles can be integrated with medical and life sciences to translate biomedical discoveries into bedside technologies for treating many diseases, such as diabetes and cancers. The program will expose students to medical science, biology, biochemistry, pharmaceutical sciences, neuroscience and cognitive science, as well as to tissue engineering, materials sciences, nanofabrications, genome editing, RNA transcriptome analysis, 3D bioprinting, cell manufacturing, and tissue biofabrication. Interactive workshops covering topics related to biomedical engineering and graduate studies and career development training will inform students of the latest developments in the fields of biomedical science and engineering and professional development opportunities in these fields. Social events related to the REU program will allow students to interact with other REU students on campus facilitating peer learning and collegiality. Field trips to industry sites will introduce students to applications of biotechnology development. The combination of research training, workshops, social events, and field trips will provide students with a foundation in biomedical engineering research, which they can apply to enriching their professional development.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物医学科学的快速发展导致各个职业级别的生物医学科学家和工程师供不应求，迫切需要教育和培训更多的年轻人掌握生物医学科学和工程所需的技能和知识。为了满足这一需求，宾汉姆顿大学 (BU-SUNY) 将举办为期 10 周的夏季 REU 项目，每年培训 10 名转化生物医学科学与工程本科生。该项目将为本科生提供综合生物医学转化科学和技术开发方面的强化多学科实践研究和专业发展培训。该计划预计将开发一个领导渠道，帮助学生在这些领域的研究生学习或职业和专业培训中取得进步。生物医学科学家与工程师的合作促成了这一新颖而独特的 REU 项目的开发。参与的 14 名教员总共培训了近 684 名 REU 学生，并由本科生共同撰写了 80 篇经过同行评审的研究文章。波士顿大学对本科教育和研究的坚定承诺将确保拟议的 REU 计划的成功。参与该项目的教师导师广泛而有凝聚力的研究兴趣使得我们能够设计和实施一个充满活力的夏季 REU 项目，为本科生提供 T 型专业培训机会。将努力招收代表性不足的群体的学生，例如女性、少数民族学生以及本科生研究培训有限的本科院校和社区学院的学生。 REU 项目的成果将在全国会议上传播，并在同行评审期刊上发表。REU 项目将为学生提供学习如何将工程原理与医学和生命科学相结合，将生物医学发现转化为临床治疗技术的机会。许多疾病，例如糖尿病和癌症。该项目将使学生接触医学科学、生物学、生物化学、制药科学、神经科学和认知科学，以及组织工程、材料科学、纳米制造、基因组编辑、RNA转录组分析、3D生物打印、细胞制造和组织生物制造。涵盖生物医学工程和研究生学习以及职业发展培训相关主题的互动研讨会将使学生了解生物医学科学与工程领域的最新发展以及这些领域的专业发展机会。与 REU 项目相关的社交活动将使学生能够与校园内的其他 REU 学生互动，促进同伴学习和合作。行业现场实地考察将向学生介绍生物技术开发的应用。研究培训、研讨会、社交活动和实地考察相结合，将为学生提供生物医学工程研究的基础，他们可以利用这些基础来丰富自己的专业发展。该奖项反映了 NSF 的法定使命，经评估认为值得支持利用基金会的智力优势和更广泛的影响审查标准。

项目成果

Inducing Tumor Suppressive Microenvironments through Genome Edited CD47−/− Syngeneic Cell Vaccination

通过基因组编辑的 CD47™/™ 同基因细胞疫苗诱导肿瘤抑制微环境

• DOI: 10.1038/s41598-019-56370-6
• 发表时间: 2019-12-01
• 期刊: Scientific Reports
• 影响因子: 4.6
• 作者: Subhadra Jayaraman Rukmini;Huanjing Bi;Puloma Sen;B. Everhart;Sha Jin;K. Ye
• 通讯作者: K. Ye