An engineering biology approach for sustainable production of omega 3 and pigments from microalgae

一种利用微藻可持续生产 omega 3 和色素的工程生物学方法

• 批准号: 10107393
• 金额: $ 12.46万
• 依托单位: MIALGAE LTD
• 依托单位国家: 英国
• 项目类别: Launchpad
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10107393
• 关键词: engineering; biology; approach; sustainable; production

Omega-3 oils are essential for human health, with the main dietary source of these fatty acids being fish. However, approximately 90% of global fisheries are overexploited or fully depleted, and therefore cannot act as a sustainable source. In place of natural fisheries, the United Nations projects that aquaculture will provide 60% of global fish consumption by 2030\. However, farmed fish do not produce omega-3 oils and other key nutrients themselves, instead accumulating them from fish further down the food chain. Aquaculture is therefore also reliant on unsustainable practices, as approximately 65 - 70% of the fishmeal and fish oil required as feed is sourced from of pelagic fish harvested specifically for this purpose. More sustainable approaches to feed production are therefore required to meet the increase in consumer demand for seafood whilst also protecting our oceans.MiAlgae's proprietary technology applies a circular economy approach to sustainably produce omega-3 and pigments from co-products of the Scottish whisky industry. The co-products, including pot ale and spent lees, are used as a feedstock to grow microalgae, and the resulting biomass is the basis of our recently launched NaturAlgae product. NaturAlgae is a omega-3 rich powder that can be used as a feed ingredient in the aquaculture and pet food industries. The fermentation also produces trace amounts of carotenoids, which are valued for their colour and antioxidant properties, with the only other output from the process being clean water.The more efficiently MiAlgae's technology can turn whisky co-products to omega-3 and other products of interest, the more fishmeal and fish oils can be replaced by sustainable alternatives. This project aims to develop enabling technologies (namely a transformation protocol and genome sequence) that can be used to facilitate an engineering biology approach in our microalgal stain. By allowing us to rationally engineer our strain, these technologies will enable MiAlgae to improve process efficiency and increase yields of omega-3 and carotenoids, thereby maximising the value added to each batch of distillery co-product.

Omega-3油对于人类健康至关重要，这些脂肪酸是鱼类的主要饮食来源。但是，大约90％的全球渔业被过度开发或充分耗尽，因此不能充当可持续的来源。联合国项目代替了自然渔业，其水产养殖将在2030年提供60％的全球鱼类消费量。但是，养殖鱼本身不会生产omega-3油和其他关键营养素，而是将它们从食物链沿着鱼类进一步积累。因此，水产养殖也依赖于不可持续的实践，因为大约65-70％的鱼粉和鱼油是为此目的而收集的骨膜鱼所需的鱼油和鱼油。因此，需要更可持续的饲料生产方法来满足消费者对海鲜的需求的增加，同时也保护我们的海洋。包括锅啤酒和用过的液体在内的副产品被用作生长微藻的原料，由此产生的生物量是我们最近推出的天然饮品的基础。 NaturalGae是一种富含omega-3的粉末，可以用作水产养殖和宠物食品行业中的饲料成分。发酵还会产生痕量的类胡萝卜素，这些类胡萝卜素以其颜色和抗氧化特性所重视，而该过程中唯一的其他输出是清洁水。米尔戈（Mialgae）的技术更有效地将威士忌的副产品转化为欧米茄3和其他感兴趣的产品，而更多的渔市和鱼油可以用可持续的替代品替代。该项目旨在开发启示技术（即转化方案和基因组序列），可用于促进我们的微藻污渍中的工程生物学方法。通过允许我们合理地设计我们的应变，这些技术将使Mialgae能够提高过程效率并提高omega-3和类胡萝卜素的产量，从而最大程度地提高每批酿酒厂的含量。