Collaborative Research: Formation of a High Flux Student Research Network (HF-SRN) as a Laboratory for Enhancing Interaction in the PoLS SRN

合作研究：建立高通量学生研究网络（HF-SRN）作为增强 PoLS SRN 互动的实验室

• 批准号: 1806903
• 负责人: Arpita Upadhyaya
• 金额: $ 132.3万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1806903&HistoricalAwards=false
• 关键词: Collaborative; Research; Formation; Flux; Student

The NSF Physics of Living Systems (PoLS) Student Research Network (SRN) strives to unite students and faculty working at the interface of physics and biology at different institutions ("nodes") within the US and internationally. A well functioning virtual network could give students at local nodes the ability to take advantage of global educational and research opportunities in PoLS. PoLS is a diverse field, and is composed of researchers and students from varied backgrounds. No single institution can offer (1) the breadth and depth of research and (2) courses that both cover the relevant intellectual landscape and provide in-depth training for students. Such training is critical to create the next generation of researchers who can contribute quantitatively to biophysics, with the ability to move between biology, physics, mathematics, and engineering; PoLS students have important roles to play in this next generation. In addition, no single institution has the range of equipment needed to study PoLS on the enormous range of time and length scales encountered in biological systems. Finally, few single institutions can fruitfully integrate science and engineering to inspire biomedical, robotic and prosthetic devices that will result from basic PoLS research. The HF-SRN will create an environment for students in which they can work among various disciplines while maintaining the physics mindset (simplified systems, few parameter predictive models) and developing new physics. This network will train students (paraphrasing Philip Nelson in his 2008 Biological Physics textbook) "who can switch fluidly between both kinds of brain: the `developmental/historical/complex' sciences and the 'universal/ahistorical/reductionist'." As significant collaborative and educational flux develops within the HF-SRN, successful activities will be broadened to the other US nodes (ultimately with the expectation to engage PoLS SRN international partners). The evaluation plan will help guide aspects of the HF-SRN that could increase flux in other programs in the NSF Science Across Virtual Institutes initiative. More broadly, PoLS SRN students can be leaders in the next generation of researchers who blend biology and physics research seamlessly. Such students will create materials which will seed future K-12 as well as university PoLS curricula. Efforts will be made to extend the educational and research efforts developed within the HF-SRN (and entire SRN) to a broader community including local minority serving institutions. Advances in PoLS can lead to advances in applications such as genome editing, cancer dynamics, robotics and human-assist devices, among others.During the last period of funding as part of the SRN, the Georgia Tech, Harvard and Maryland nodes have advanced their respective PoLS programs, developing cohesive local communities. The goal of this project is to further develop opportunities for students (and their ideas) to "flow" more easily within the SRN and thereby discover working principles of increased human network flux that can be transferred into the larger SRN. To do so, significant interactions (and evaluations of those interactions) will be developed among three existing SRN nodes (adding Emory as a subcontract to Georgia Tech), forming a "High Flux SRN" (HF-SRN). The HF-SRN will engage in activities such as 1) Collaborative Focused Research Projects, which span nodes and are "built to succeed" by leveraging student and faculty expertise in current projects; 2) Student-Led Dynamic Working Groups (e.g., in biomolecular, microbial, cellular and organismal physics) leveraging faculty research strengths and student interest to develop cross-node communities for these topics. 3) Student-Led Bootcamps: intense 2-3 day tutorials (e.g., microscopy, robophysics, image analysis) with cross-subgroup cutting themes, open to HF-SRN members and held at a particular node; 4) Student-Led Workshops: composed of talks, poster and discussion sessions, inviting the entire PoLS SRN; 5) Curriculum development via open-source course materials, integrating complementary expertise across nodes. All activities will be evaluated and assessed by a Council composed of the lead PIs at each node. This project is being jointly supported by the Physics of Living Systems program in the Division of Physics, the Molecular Biophysics Program in the Division of Molecular and Cellular Biosciences, and the Modulation Program in the Division of Integrative Organismal Systems.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NSF的生活系统物理学（POLS）学生研究网络（SRN）致力于在美国和国际上在不同机构（“节点”）的物理和生物学界面团结学生和教职员工。功能良好的虚拟网络可以使当地节点的学生能够利用POL中的全球教育和研究机会。 POLS是一个多样的领域，由来自不同背景的研究人员和学生组成。没有一个机构可以提供（1）研究的广度和深度以及（2）涵盖相关智力景观并为学生提供深入培训的课程。这种培训对于创建下一代研究人员至关重要，这些研究人员可以在生物学，物理学，数学和工程学之间进行定量贡献生物物理学贡献； POLS学生在下一代中扮演着重要角色。此外，没有一家机构拥有研究POR在生物系统中遇到的大量时间和长度尺度的范围所需的设备范围。最后，很少有单一的机构能够将科学和工程融为一体，以激发基本POLS研究所产生的生物医学，机器人和假肢设备。 HF-SRN将为学生创建一个环境，在该环境中，他们可以在各个学科中工作，同时保持物理心态（简化系统，很少的参数预测模型）并开发新的物理学。该网络将培训学生（在他的2008年生物物理学教科书中释义菲利普·尼尔森（Philip Nelson））“他们可以在两种大脑之间流畅地切换：``发育/历史/复杂/复杂的科学''和'通用/阿学/历史/还原学家'。”随着HF-SRN内部的重要协作和教育通量的发展，成功的活动将扩大到其他美国节点（最终希望与POLS SRN International Partners互动）。评估计划将有助于指导HF-SRN的各个方面，这些方面可能会在虚拟机构倡议中增加NSF科学其他计划中的其他磁通量。更广泛地说，POLS SRN学生可以成为下一代研究人员的领导者，他们无缝融合生物学和物理研究。这样的学生将创建材料，这些材料将使未来的K-12和大学POLS课程播种。将做出努力，以将HF-SRN（以及整个SRN）内开发的教育和研究工作扩展到一个更广泛的社区，包括当地的少数派服务机构。 PORS的进步可能会导致在基因组编辑，癌症动力学，机器人和人类辅助设备等应用方面的进步。在作为SRN的一部分，佐治亚理工学院，哈佛大学和马里兰州节点的最后一段时期的资金中，他们各自的POLS计划提出了发展，并发展了凝聚力的地方社区。该项目的目的是进一步为学生（及其思想）在SRN中更容易“流动”的机会，从而发现人网络通量增加的工作原理，这些原则可以转移到较大的SRN中。为此，将在三个现有的SRN节点（将Emory作为分包合同中添加到Georgia Tech）之间，形成“ High Flux SRN”（HF-SRN），将在三个现有的SRN节点（将Emory添加为分包合同）之间开发出重大的相互作用（以及对这些相互作用的评估）。 HF-SRN将从事诸如1）以协作性研究项目之类的活动进行活动，该项目跨越了节点，并通过利用学生和教师专业知识来“成功”，以实现当前项目； 2）由学生主导的动态工作组（例如，在生物分子，微生物，细胞和有机物物理学中）利用教师研究长处和学生兴趣，以开发这些主题的跨节点社区。 3）由学生主导的训练营：具有跨套件切割主题的激烈的2-3天教程（例如显微镜，机器人物理学，图像分析），向HF-SRN成员开放，并以特定的节点保存； 4）由学生主导的讲习班：由演讲，海报和讨论会议组成，邀请整个POLS SRN； 5）通过开源课程材料开发课程，并整合跨节点的互补专业知识。所有活动将由每个节点的铅PI组成的理事会进行评估和评估。该项目在物理学部的生命系统计划，分子和细胞生物科学划分的分子生物物理学计划以及在综合有机体系统划分的调制计划中共同支持。这奖反映了NSF的法定任务，并通过使用基金会的智力效果和广阔的范围进行评估，以评估值得评估。

项目成果

Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates

• DOI: 10.1073/pnas.2021135118
• 发表时间: 2021-06-01
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Fischer, Robert S.;Sun, Xiaoyu;Waterman, Clare M.
• 通讯作者: Waterman, Clare M.

Dynamic switching of transcriptional regulators between two distinct low-mobility chromatin states

• DOI: 10.1126/sciadv.ade1122
• 发表时间: 2023-06-16
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Wagh，Kaustubh;Stavreva，Diana A.;Hager，Gordon L.
• 通讯作者: Hager，Gordon L.

Tensile force-induced cytoskeletal remodeling: Mechanics before chemistry

• DOI: 10.1371/journal.pcbi.1007693
• 发表时间: 2020-06-01
• 期刊: PLOS COMPUTATIONAL BIOLOGY
• 影响因子: 4.3
• 作者: Li, Xiaona;Ni, Qin;Jiang, Yi
• 通讯作者: Jiang, Yi