GOALI: Laser-based Layer-by-Layer Nanomanufacturing of Water Insoluble Drug-Loaded Thin Films

GOALI：基于激光的逐层纳米制造水不溶性载药薄膜

基本信息

批准号：
1762202
负责人：
Roger Narayan
金额：
$ 20.39万
依托单位：
North Carolina State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1762202&HistoricalAwards=false
关键词：
GOALI Laser based Layer Nanomanufacturing

项目摘要

This Grant Opportunity for Academic Liaison with Industry (GOALI) award supports research that contributes new knowledge related to the use and understanding of a nanomanufacturing process known as matrix assisted pulsed laser evaporation for processing pharmaceuticals. Matrix assisted pulsed laser evaporation has the potential to revolutionize the way pharmaceuticals that do not dissolve in water are manufactured. Manufacturing processes are available to place these pharmaceuticals within small spherical containers that are known as liposomes. However, the high cost to make pharmaceutical-loaded liposomes makes accessibility to these pharmaceuticals difficult for individuals and communities with limited resources. Matrix assisted pulsed laser evaporation involves layer-by-layer deposition of drug-loaded thin films on three-dimensional printed needles for delivery with greater precision and lower cost than current technologies. New combinatorial chemistry, drug design, and drug screening mechanisms have led to the development of a large number of new water-insoluble pharmaceuticals. This research advances the production mechanisms for these drugs thus benefiting the U.S. pharmaceutical industry and improving patient quality of life. This GOALI project involves several disciplines including nanotechnology, laser technology, pharmaceutical science, manufacturing science, and materials science. It helps broaden participation of women and underrepresented minorities in research through activities at the North Carolina Museum of Natural Sciences and local schools. Collaborations between North Carolina State University and Lynntech, a company that develops medical products, propels commercialization and clinical translation of nanomanufacturing of pharmaceuticals using matrix assisted pulsed laser evaporation technology.The matrix assisted pulsed laser evaporation nanoscale manufacturing process can overcome several limitations associated with conventional pharmaceutical manufacturing techniques such as cost and delivery precision. By this process, drug-containing thin films can be formed on drug delivery substrates with excellent control over coating thickness, roughness, and homogeneity. This award overcomes several scientific barriers to realize the full potential of matrix assisted pulsed laser evaporation for processing pharmaceuticals that do not dissolve in water. This research is to fill the knowledge gap on the relationships among processing parameters, structure, chemical properties, and biological functionality for a drug that can be used to treat a common type of skin cancer (basal cell carcinoma) as well as fungal infections. The development of layered nanocomposite films, which extend the amount of time over which the drug is released, has the potential to reduce the number of times that a drug needs to be administered for effective treatment.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该学术与工业联络机会 (GOALI) 奖项支持研究贡献与使用和理解纳米制造工艺（称为用于加工药物的基质辅助脉冲激光蒸发）相关的新知识。基质辅助脉冲激光蒸发有可能彻底改变不溶于水的药物的制造方式。制造工艺可将这些药物放入称为脂质体的小型球形容器中。然而，制造装载药物的脂质体的成本高昂，使得资源有限的个人和社区难以获得这些药物。基质辅助脉冲激光蒸发涉及在三维打印针上逐层沉积载药薄膜，与现有技术相比，其输送精度更高，成本更低。新的组合化学、药物设计和药物筛选机制导致了大量新型水不溶性药物的开发。这项研究改进了这些药物的生产机制，从而使美国制药业受益并改善患者的生活质量。该GOALI项目涉及纳米技术、激光技术、制药科学、制造科学、材料科学等多个学科。它通过北卡罗来纳州自然科学博物馆和当地学校的活动，帮助扩大妇女和代表性不足的少数群体对研究的参与。北卡罗莱纳州立大学与 Lynntech 公司合作，该公司开发医疗产品，利用基质辅助脉冲激光蒸发技术推动药物纳米制造的商业化和临床转化。基质辅助脉冲激光蒸发纳米级制造工艺可以克服传统药物的一些局限性制造技术，例如成本和交付精度。通过该过程，可以在药物递送基底上形成含药薄膜，并且对涂层厚度、粗糙度和均匀性具有良好的控制。该奖项克服了多项科学障碍，充分发挥基质辅助脉冲激光蒸发在处理不溶于水的药物方面的潜力。这项研究旨在填补可用于治疗常见类型皮肤癌（基底细胞癌）和真菌感染的药物的加工参数、结构、化学性质和生物功能之间关系的知识空白。层状纳米复合材料薄膜的开发可以延长药物的释放时间，有可能减少有效治疗所需的药物给药次数。该奖项反映了 NSF 的法定使命，并被视为值得通过使用基金会的智力优点和更广泛的影响审查标准进行评估来支持。