NSF/FDA Scholar in Residence Program on In Vitro Biological Characterization of 3D Printed Small-Scale Medical Devices

NSF/FDA 3D 打印小型医疗器械体外生物学表征常驻学者项目

• 批准号: 1445727
• 负责人: Roger Narayan
• 金额: $ 13万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-11-01 至 2017-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1445727&HistoricalAwards=false
• 关键词: NSF; FDA; Scholar; Residence; Program

PI: Narayan, Roger J.Proposal: 1445727Title: NSF/FDA Scholar in Residence Program on In Vitro Biological Characterization of 3D Printed Small-Scale Medical DevicesSignificanceThe data obtained in this project will serve as the basis for a material property-biological performance database, in which the relationship between in vitro cell-material interactions, protein adsorption, and material processing parameters will be considered. The regulatory science approach will provide a repertoire of methods and tools to understand the fundamental tissue-material interactions for complex and innovative device technologies.Technical DescriptionIn the proposed Scholar-in-Residence (SIR) program, a 3D printing technique known as multi-focus two photon polymerization will be used to create solid tissue barb adhesives with microscale features for tissue penetration and sub-microscale features for cell ingrowth out of a zirconium oxide hybrid material. Tissue barbs are innovative small-scale devices with potential use in wound closure and healing. They will examine use of biocompatible photoinitiators (e.g., riboflavin-triethanolamine mixtures and riboflavin-arginine mixtures) for two photon polymerization-based 3D printing. They will also evaluate incorporation of an electrochemical sensor for monitoring of creatinine within the tissue barb adhesive. In the proposed program, they will collaborate with FDA colleagues to evaluate the in vitro biocompatibility of tissue barb materials that contain sub-micrometer scale pores and creatinine sensor materials using appropriate cells (e.g., dermal fibroblasts and epidermal keratinocytes).

PI：Narayan，Roger J. 提案：1445727 标题：NSF/FDA 3D 打印小型医疗器械体外生物学表征驻场学者项目意义该项目中获得的数据将作为材料特性-生物性能数据库的基础，其中将考虑体外细胞-材料相互作用、蛋白质吸附和材料加工参数之间的关系。监管科学方法将提供一系列方法和工具，以了解复杂和创新设备技术的基本组织-材料相互作用。技术描述在拟议的常驻学者 (SIR) 计划中，一种称为多焦点的 3D 打印技术两个光子聚合将用于制造固体组织倒钩粘合剂，该粘合剂具有用于组织穿透的微米级特征和用于细胞向内生长的氧化锆混合材料的亚微米级特征。组织倒刺是一种创新的小型装置，可用于伤口闭合和愈合。他们将研究生物相容性光引发剂（例如核黄素-三乙醇胺混合物和核黄素-精氨酸混合物）在基于双光子聚合的 3D 打印中的使用。他们还将评估用于监测组织倒刺粘合剂内肌酸酐的电化学传感器的结合情况。在拟议的计划中，他们将与 FDA 同事合作，使用适当的细胞（例如真皮成纤维细胞和表皮角质形成细胞）评估含有亚微米级孔的组织倒刺材料和肌酐传感器材料的体外生物相容性。