NSF/FDA Scholar in Residence Program on In Vitro Biological Characterization of 3D Printed Small-Scale Medical Devices

NSF/FDA 3D 打印小型医疗器械体外生物学表征常驻学者项目

• 批准号: 1445727
• 负责人: Roger Narayan
• 金额: $ 13万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-11-01 至 2017-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1445727&HistoricalAwards=false
• 关键词: NSF; FDA; Scholar; Residence; Program; NSF; FDA; Scholar; Residence; Program

PI: Narayan, Roger J.Proposal: 1445727Title: NSF/FDA Scholar in Residence Program on In Vitro Biological Characterization of 3D Printed Small-Scale Medical DevicesSignificanceThe data obtained in this project will serve as the basis for a material property-biological performance database, in which the relationship between in vitro cell-material interactions, protein adsorption, and material processing parameters will be considered. The regulatory science approach will provide a repertoire of methods and tools to understand the fundamental tissue-material interactions for complex and innovative device technologies.Technical DescriptionIn the proposed Scholar-in-Residence (SIR) program, a 3D printing technique known as multi-focus two photon polymerization will be used to create solid tissue barb adhesives with microscale features for tissue penetration and sub-microscale features for cell ingrowth out of a zirconium oxide hybrid material. Tissue barbs are innovative small-scale devices with potential use in wound closure and healing. They will examine use of biocompatible photoinitiators (e.g., riboflavin-triethanolamine mixtures and riboflavin-arginine mixtures) for two photon polymerization-based 3D printing. They will also evaluate incorporation of an electrochemical sensor for monitoring of creatinine within the tissue barb adhesive. In the proposed program, they will collaborate with FDA colleagues to evaluate the in vitro biocompatibility of tissue barb materials that contain sub-micrometer scale pores and creatinine sensor materials using appropriate cells (e.g., dermal fibroblasts and epidermal keratinocytes).

PI：Narayan，Roger J.Proposal：1445727title：NSF/FDA居住学者在本项目中获得的3D印刷小规模的医学性偏差数据的体外生物学表征的居住计划，该项目获得的数据将作为材料性质生物生物学数据的基础，在材料生物生物学数据库中，在体外互动中互动，蛋白酶构成蛋白质质量，蛋白酶构成蛋白酶，蛋白酶构成蛋白质，该蛋白质构成的蛋白质， 经过考虑的。监管科学方法将提供一系列方法和工具，以了解复杂和创新的设备技术的基本组织 - 材料相互作用。技术描述拟议的居住学者（SIR）计划，这是一种3D打印技术，一种被称为多物质的多个光子型光子型的三个印刷技术将用于创建与固体组织的固体式渗透性特征，并将其用于固体式培训特征。从氧化锆杂种材料中。组织倒钩是创新的小规模设备，可在伤口闭合和愈合中使用。他们将检查使用生物相容性的光导剂（例如核黄素 - 三乙醇胺混合物和核黄素 - 精氨酸混合物）用于两个基于光子聚合的3D打印。他们还将评估掺入电化学传感器，以监测肌酐在组织倒钩粘合剂中。在拟议的计划中，他们将与FDA同事合作，评估使用适当细胞（例如，皮肤成纤维细胞和表皮角膜生比例）的组织倒钩材料的体外生物相容性，该组织倒钩材料的体外生物相容性和肌酐传感器材料包含亚微米尺度的孔和肌酐传感器材料。