CNIC: US-Australia Planning Visits for UNC-NCSU-Queensland Partnership on Novel Materials and Devices for Transdermal Sensors

CNIC：美国-澳大利亚计划访问北卡罗来纳大学-北卡罗来纳州立大学-昆士兰大学关于透皮传感器新型材料和设备的合作伙伴关系

• 批准号: 1401950
• 负责人: Roger Narayan
• 金额: $ 4.95万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1401950&HistoricalAwards=false
• 关键词: CNIC; US; Australia; Planning; Visits

In this CNIC program, Dr. Tarl Prow (Deputy Director, Dermatology Research Center, University of Queensland) and the PI propose an innovative mechanism for minimally invasive and in situ detection of melanoma progression using novel microscale devices that contain microneedles as well as microarrays, which detect chemical processes specific to melanoma. Three graduate research assistants (US citizens or US permanent residents) will travel to Dr. Prow's laboratory for four month periods to perform the following tasks: (1) synthesis of microneedle devices for transdermal detection of melanoma, (2) microneedle-skin characterization and mechanical characterization, and (3) studies to assess the functionality of microneedle-microarray devices for detection of melanoma. The goal of the proposed effort is to catalyze new international collaborations between the PI and Dr. Prow, who are uniquely qualified to achieve the program goals. Dr. Prow's lab has pioneered efforts involving microneedle-based detection of melanoma. The PI?s lab has pioneered research efforts involving rapid prototyping of microneedles for transdermal drug delivery and sensing. The project will contrbute to improved melanoma treatment by enabling small samples to be repeatedly obtained from single lesions over time, thus allowing molecular mechanisms involved in melanomagenesis to be better understood. The PI is leading a series of lectures and scientific demonstrations in Raleigh for young people in the broader community; these "Science Saturday" events take place at the North Carolina Museum of Natural Sciences. The PI and students will incorporate results and demonstration materials from the project in these events.

在这个 CNIC 项目中，Tarl Prow 博士（昆士兰大学皮肤病学研究中心副主任）和 PI 提出了一种创新机制，使用包含微针和微阵列的新型微型设备来微创和原位检测黑色素瘤进展，检测黑色素瘤特有的化学过程。三名研究生研究助理（美国公民或美国永久居民）将前往 Prow 博士的实验室为期四个月，执行以下任务：(1) 合成用于经皮检测黑色素瘤的微针装置，(2) 微针皮肤表征和机械表征，以及（3）评估微针微阵列装置检测黑色素瘤功能的研究。拟议工作的目标是促进 PI 和 Prow 博士之间新的国际合作，他们具有实现项目目标的独特资格。 Prow 博士的实验室在基于微针的黑色素瘤检测方面处于领先地位。 PI 实验室率先开展了涉及用于透皮药物输送和传感的微针快速原型设计的研究工作。该项目将通过随着时间的推移从单个病变中重复获取小样本，从而有助于改善黑色素瘤的治疗，从而更好地了解黑色素瘤发生的分子机制。 PI 正在罗利为更广泛社区的年轻人举办一系列讲座和科学演示；这些“科学星期六”活动在北卡罗来纳州自然科学博物馆举行。 PI 和学生将在这些活动中纳入项目的成果和演示材料。