MRI: Acquisition of a 3D printer for Additive Manufacturing of Functional Materials for Biological Applications
MRI:采购一台 3D 打印机,用于生物应用功能材料的增材制造
基本信息
- 批准号:1726035
- 负责人:
- 金额:$ 19.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2019-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This Major Research Instrumentation (MRI) grant will enable the acquisition of a 3D printer for additive manufacturing of functional materials for biological applications. The PIs at Florida A&M University (FAMU) are exploring processes, structures and performance measures of novel engineered materials that will lead to significant achievements in material processing that have profound biological applications. This grant fills a gap in instrumentation at FAMU and enhances the current synergy across the PIs' research platform and offer unique solutions for different funded projects and thrust areas in the biological arena such as drug delivery, electrospinning, cancer therapy and scaffolds for bone tissue engineering. The project brings together researchers from chemical and biomedical engineering, pharmaceutical sciences, chemistry and industrial engineering and will play a key role in the education of undergraduate, graduate minority students and postdoctoral fellows across different disciplines. In particular, for the first time it will allow cross talk between the biological scientists and engineers thus resulting in development of novel fundamental science and devices that will play a key role in biomedical sciences. Introduction of materials education with the help of acquired printer and proposed research in the curriculum at different departments will provide a means to motivate minority students, retain them and enhance their scientific capability thus producing a pool of well-trained scientists. This Major Research Instrumentation (MRI) grant will support acquisition of a state-of-the-art 3D printer with unique capabilities of multi-material printing and the ability to pattern these multiple materials in three dimensions. Research component involves a) development of a novel bioprinting platform to print co-cultures using cancer cells and tumor associated fibroblasts which can simulate the human stromal characteristics b) integration of electrospinning and 3D printing to develop hierarchically structured scaffolds for tissue engineering c) 3D printed models for transdermal drug delivery of molecules like Testosterone and Estradiol and scaffolds for bone tissue engineering. 3D bio-printing of cancer cells shows significant promise for creating complex tissue and organ mimics and eliminates the gap between the in vitro drug screening and animal models. The requested nScrypt Biological Architectural Tool (BAT) system is a bio-printing platform with the ability to host up to four separate materials and print on curved surfaces or print 3D structures with a motion control accuracy of ±5 microns and repeatability up to ±2 microns in XY. The Smart pump included in the printer system has the ability to print a wide variety of biomaterials including living cells. The ability to control separate pumps/devices all under one software control and one platform provides a unique multilayer, multi-material and multi-structure capability which makes this printer ideal for the proposed projects.
这项重大研究仪器 (MRI) 拨款将用于购买一台 3D 打印机,用于生物应用功能材料的增材制造。 佛罗里达农工大学 (FAMU) 的 PI 正在探索新型工程材料的工艺、结构和性能测量,这将引领未来。这笔资助填补了 FAMU 仪器方面的空白,增强了 PI 研究平台的当前协同作用,并为生物领域的不同资助项目和重点领域提供了独特的解决方案,例如该项目汇集了来自化学和生物医学工程、制药科学、化学和工业工程的研究人员,将在本科生、少数族裔研究生和博士后的教育中发挥关键作用。特别是,它将首次允许生物科学家和工程师之间进行交流,从而开发出新的基础科学和设备,这些设备将在材料教育的帮助下在生物医学科学中发挥关键作用。购买了打印机并在课程中提出了研究不同院系的项目将提供一种方法来激励少数族裔学生、留住他们并提高他们的科学能力,从而培养一批训练有素的科学家。这项重大研究仪器 (MRI) 拨款将支持购买最先进的 3D 设备。具有独特的多材料打印功能以及在三个维度上对这些多种材料进行图案化的打印机的研究部分涉及a)开发一种新型生物打印平台,以使用癌细胞和肿瘤相关成纤维细胞打印共培养物,该平台可以模拟人类基质。特点 b) 整合静电纺丝和 3D 打印开发用于组织工程的分层结构支架 c) 用于睾酮和雌二醇等分子透皮药物输送的 3D 打印模型以及用于骨组织工程的 3D 生物打印支架显示出创建复杂组织和器官的巨大前景。模拟并消除了体外药物筛选和动物模型之间的差距。所需的 nScrypt 生物架构工具 (BAT) 系统是一个生物打印平台,能够承载多达四个独立的模型。材料并在曲面上打印或打印 3D 结构,运动控制精度为 ±5 微米,XY 重复精度高达 ±2 微米。打印机系统中包含的智能泵能够打印包括活细胞在内的各种生物材料。能够在一个软件控制和一个平台下控制单独的泵/设备,提供了独特的多层、多材料和多结构功能,使这款打印机成为拟议项目的理想选择。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Subramanian Ramakrishnan其他文献
Analysis of the Long Time Behavior of Enzymatic Cellulose Hydrolysis Kinetics
酶促纤维素水解动力学的长期行为分析
- DOI:
10.1515/ijcre-2017-0087 - 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Subramanian Ramakrishnan;G. Brodeur;J. Telotte - 通讯作者:
J. Telotte
20 m s-resolved high-throughput X-ray photon correlation spectroscopy on a 500k pixel detector enabled by data-management workflow
通过数据管理工作流程实现 50 万像素探测器上的 20 m 分辨率高通量 X 射线光子相关光谱
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Qingteng Zhang;E. M. Dufresne;Y. Nakaye;P. Jemian;Takuto Sakumura;Yasutaka Sakuma;Joseph D. Ferrara;Piotr Maj;Asra Hassan;Divya Bahadur;Subramanian Ramakrishnan;F. Khan;S. Veseli;Alec R. Sandy;Nicholas Schwarz;S. Narayanan - 通讯作者:
S. Narayanan
Subramanian Ramakrishnan的其他文献
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{{ truncateString('Subramanian Ramakrishnan', 18)}}的其他基金
Targeted Infusion Project: Enhancing Retention in the Chemical & Biomedical Engineering Program at Florida A and M University through Integrated Research, Teaching and Retention
靶向输注项目:增强化学品的保留
- 批准号:
2306449 - 财政年份:2023
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
HBCU-RISE: Enhancement of Research and Education Infrastructure in the Chemistry and Engineering of Multifunctional Materials
HBCU-RISE:加强多功能材料化学与工程领域的研究和教育基础设施
- 批准号:
2219558 - 财政年份:2022
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Collaborative Research: Understanding Stochastic Spatiotemporal Dynamics of Epidemic Spread to Improve Control Interventions - From COVID-19 to Future Pandemics
合作研究:了解流行病传播的随机时空动态以改进控制干预措施 - 从 COVID-19 到未来的大流行
- 批准号:
2140405 - 财政年份:2022
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
CREST Center for Complex Materials Design for Multidimensional Additive Processing (CoManD)
CREST 多维增材加工复杂材料设计中心 (CoManD)
- 批准号:
1735968 - 财政年份:2017
- 资助金额:
$ 19.3万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: When Descriptive Representatives' Faces Don't Match Their Races: Inconsistent Attributes and Evaluations of Multiracial Officials
博士论文研究:当描述性代表的面孔与种族不匹配时:多种族官员的不一致属性和评价
- 批准号:
1647186 - 财政年份:2017
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Building Social Science Data Infrastructure: The 2016 National Asian American Survey
建设社会科学数据基础设施:2016 年全国亚裔美国人调查
- 批准号:
1558986 - 财政年份:2016
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Targeted Infusion Project: Enhancement of Materials Science Education through Active Learning at Florida A&M University
有针对性的注入项目:通过佛罗里达 A 的主动学习加强材料科学教育
- 批准号:
1623206 - 财政年份:2016
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Research Initiation Award Grant - Colloidal Mixtures: Microstructure and Mechanics
研究启动奖 - 胶体混合物:微观结构和力学
- 批准号:
1238524 - 财政年份:2012
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: The Effect of Empathy on Public Opinion on Immigration
博士论文研究:同理心对移民舆论的影响
- 批准号:
1124608 - 财政年份:2011
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
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