GOALI: SusChem: Organocatalysis: A Platform for Sustainable Polymer Chemistry

目标：SusChem：有机催化：可持续聚合物化学平台

• 批准号: 1607092
• 负责人: Robert Waymouth
• 金额: $ 63.1万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2020-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1607092&HistoricalAwards=false
• 关键词: GOALI; SusChem; Organocatalysis; Platform; Sustainable

Polymers are highly useful modern materials for clothes, furniture, electronic devices, household products and appliances, food packages, and medicine. Polymer properties are controlled by the chemical structures of its building blocks. The preparation of polymers with new or improved properties requires the use of new blocking blocks, and the economical manufacturing of these polymers requires the development of efficient synthetic approaches to link the new building blocks together. In this project, Professor Robert Waymouth of Stanford University and Dr. James Hedrick of IBM Almaden Laboratories are developing a broad and versatile platform of methods to enable the synthesis of new building blocks and well-defined biodegradable polymers with novel structures, properties and function. This project provides a model academic / industrial collaboration between Stanford and IBM Almaden Laboratories under the auspices of NSF's GOALI program (Grant Opportunities for Academic Liason with Industry). It engages graduate students and postdoctoral scholars in a highly interdisciplinary and collaborative effort. The unusual educational environment embraces both academic and industrial perspectives on the translation of basic science into technology. This project funded by the Macromolecular, Supramolecular and Nanochemistry program of the Chemistry Division focuses on the simultaneous development of new science and technologies. Specifically, this project aims to develop 1) new organocatalysts that are active and selective for ring-opening polymerization, 2) new strategies for the synthesis of new monomers (functionalized lactones and cyclic carbonates) that can be enchained to elicit novel properties and function for macromolecular materials, 3) a novel depolymerization reaction; and 4) new classes of "smart" water-soluble copolymers whose structures and properties can be modulated by changes in external environment. Central to the scientific approach is an emphasis on mechanistic and theoretical investigations to illuminate the mechanistic details of organocatalytic polymerization reactions, both to test evolving hypotheses on organocatalytic strategies and to provide clear scientific rationales for both the advantages and limitations of these synthetic strategies.

聚合物是非常有用的现代材料，用于衣服，家具，电子设备，家用产品和家具，食品包和药物。聚合物特性由其构建块的化学结构控制。具有新的或改进特性的聚合物的制备需要使用新的阻滞块，并且这些聚合物的经济制造需要开发有效的合成方法，以将新的构建块联系起来。在这个项目中，斯坦福大学的罗伯特·韦茅斯教授和IBM Almaden实验室的詹姆斯·赫德里克博士正在开发一个广泛而多功能的方法平台，以使新的建筑块和具有新颖的生物降解的聚合物具有新的结构，物业，物业和功能。该项目在NSF的Goali计划（为Liason的Industry Liason提供了赠款机会）下，提供了斯坦福大学和IBM Almaden实验室之间的模型学术 /工业合作。它让研究生和博士后学者参与了高度的跨学科和协作的努力。不寻常的教育环境涵盖了将基础科学转化为技术的学术和工业观点。该项目由化学部的大分子，超分子和纳米化学计划的资助侧重于同时发展新科学和技术。具体而言，该项目旨在开发1）具有积极且有选择性的新的有机催化剂，可用于开环聚合，2）可用于合成新单体（官能化的内酯和环状碳酸盐）的新策略，这些策略可以诱发，这些策略可以诱发，以引起新型材料的新颖性和功能，3）新颖的新型材料； 4）新的“智能”水溶性共聚物的新类别可以通过外部环境的变化来调节其结构和特性。科学方法的核心是强调机械和理论研究，以阐明有机催化聚合反应的机理细节，既要测试有机催化策略的不断发展的假设，又为这些合成策略的优势和限制提供了明确的科学典范。