GOALI: Organocatalytic Polymerization: New Synthetic Methods for Polymer Chemistry

目标：有机催化聚合：高分子化学的新合成方法

• 批准号: 0957386
• 负责人: Robert Waymouth
• 金额: $ 51万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0957386&HistoricalAwards=false
• 关键词: GOALI; Organocatalytic; Polymerization; New; Synthetic

The Chemical Catalysis Program supports Professor Robert M. Waymouth at Stanford University and Dr. James L Hedrick at IBM for a research project that will explore new patterns of reactivity of organic catalysts for controlled polymerization reactions. Specific objectives are to: (1) develop novel bifunctional strategies for organocatalytic polymerization reactions; (2) develop a detailed kinetic and mechanistic understanding of zwitterionic polymerizations for the synthesis of macrocyclic polymers; and (3) develop new organocatalytic methods for the synthesis of biodegradable and biocompatible polyphosphates. The zwitterionic polymerization mediated by N-heterocyclic carbenes is a new conceptual advance for the enchainment of monomers to high molecular weight cyclic polymers. Mechanistic and kinetic insights on the details of these reactions will provide a conceptual and quantitative picture of the scope, power and limitations of this new synthetic method. Organocatalytic polymerization strategies provide an environmentally friendly approach for the synthesis and recycling of major commodity polymers. Mechanistic insights on new mechanisms of enchainment will create new opportunities for the generation of novel polymer architectures, including new families of polyphosphates for biomedical applications.With the support of the Chemical Catalysis Program in the Chemistry Division at the National Science Foundation, Drs. Waymouth and Hedrick will perform research that will provide new catalytic strategies for the design of biodegradable polymers derived from renewable resources. New synthetic methods developed as part of this program will enable new strategies for the synthesis of well-defined polymer architectures. These developments will enable studies of the role of polymer structure on properties and function, issues that are fundamental to our understanding of chemistry and to the application of macromolecules in modern technologies. Broader impacts include involving students in an exceptional training environment involving a highly interdisciplinary and collaborative effort between an academic institution and an industrial laboratory. The PIs have taken an active role in recruiting and mentoring underrepresented minorities and disabled students. In addition, IBM is committing significant resources to this effort, including laboratory and office space for a postdoctoral coworker and visiting Stanford students, materials and supplies, extensive access to IBM facilities and infrastructure as well as 25% of Dr. Hedrick's time.

该化学催化计划支持斯坦福大学的罗伯特·M·韦茅斯教授和IBM的詹姆斯·赫德里克博士进行研究项目，该项目将探讨有机催化剂的新反应性模式，以进行控制聚合反应。特定目标是：（1）为有机催化聚合反应发展新型的双功能策略； （2）对大环聚合物合成的zwitterionic聚合产生详细的动力学和机械理解； （3）开发新的有机催化方法，用于合成可生物降解和生物相容性的多磷酸盐。 N-杂环碳烯介导的Z连锁聚合聚合是将单体凹入到高分子量循环聚合物的新概念上。对这些反应细节的机械和动力学见解将为这种新合成方法的范围，功率和局限性提供概念和定量的图片。器官催化聚合策略为主要商品聚合物的合成和回收提供了一种环保的方法。关于新机制的机理见解将为新型聚合物结构的产生创造新的机会，包括用于生物医学应用的新磷酸盐家族。在国家科学基金会的化学催化计划的支持下。 Waymouth和Hedrick将进行研究，将为设计可再生资源的可生物降解聚合物的设计提供新的催化策略。作为该程序的一部分开发的新合成方法将为综合定义明确的聚合物体系结构提供新的策略。这些发展将使聚合物结构对性质和功能的作用进行研究，这些问题是我们对化学的理解以及大分子在现代技术中的应用。更广泛的影响包括让学生参与一个特殊的培训环境，涉及学术机构与工业实验室之间的高度跨学科和协作努力。 PI在招募和指导代表性不足的少数民族和残疾学生中发挥了积极作用。此外，IBM正在为这项工作提供大量资源，包括用于博士后同事的实验室和办公空间，并访问了斯坦福大学的学生，材料和用品，广泛访问IBM设施和基础设施以及Hedrick博士的25％。