Mesoporous PVDF Thin Film Device for Implantable Cardiac Power Generation

用于植入式心脏发电的介孔 PVDF 薄膜器件

• 批准号: 1509369
• 负责人: Xiaojing Zhang
• 金额: $ 33.2万
• 依托单位: Dartmouth College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1509369&HistoricalAwards=false
• 关键词: Mesoporous; PVDF; Thin; Film; Device

Title: Mesoporous PVDF Thin Film Device for Implantable Cardiac Power GenerationGoals: The PI will design flexible porous polymer film power generators that convert cardiac motion into electricity to recharge implantable devices Nontechnical:Energy consumption and battery replacement are among the most challenging problems with permanently implanted biomedical devices. This research addresses the fundamental issues related to the creation of robust, scalable, energy-relevant nanomaterials and implantable microsystems that work with the extraordinary effectiveness of biomechanical motion and processes of the human heart. The potential benefits of the research in advancing the field include the development of a broad class of tunable nanomaterials networks to tailor energy conversion characteristics at the level of a single layer of nanomaterials, with potential translational applications in energy efficient biochips for diagnostic sensing, biomarker identification, and therapeutic drug delivery. Life scientists, engineering researchers, graduate and undergraduate students will be trained in key emerging areas of biomedical engineering.Technical:The objective of this project is to lay the foundation for constructing and evaluating different highly flexible and conformable multilayered piezoelectric polymer devices for converting the mechanical displacement of the heart into electrical energy. While the longevity of an average implantable cardiac defibrillators (ICD) patient with congestive heart failure has increased to 10 years after implantation, the battery for an automatic implantable cardiac defibrillators (AICD) needs to be replaced typically every 4-5 years depending on the degree of pacing and/or occurrence of defibrillation. This mismatch poses a significant and ever growing clinical and economic burden since replacing the battery requires a surgery. An innovative solution to increase AICD battery lifetimes is to harness the robust energy of the heart and convert it to electrical power. The hypothesis of this proposal is that flexible and conformable poly(vinylidene fluoride) (PVDF) polymer films containing mesoporous structures at both surfaces and throughout the bulk can be embedded inside the current dead spaces of the AICD leads to convert the mechanical motion of the heart into electrical energy by exploiting the piezoelectricity of PVDF. The research methods include: 1. Design flexible micro-power generators made of porous PVDF layers that can be interfaced with current AICD lead technology; 2. Develop computational model of cardiac power generation devices based on 3D RV heart motion to allow for optimal design and power efficiency; 3. In vitro quantification of mechano-electrical coupling of the power generator presents to an AICD lead.

标题：用于植入式心脏发电的介孔 PVDF 薄膜设备目标：PI 将设计柔性多孔聚合物薄膜发电机，将心脏运动转化为电能，为植入式设备充电非技术：能源消耗和电池更换是永久植入生物医学最具挑战性的问题之一设备。这项研究解决了与创建坚固、可扩展、与能源相关的纳米材料和可植入微系统相关的基本问题，这些材料和人体心脏的生物力学运动和过程具有非凡的有效性。该研究在推进该领域的潜在好处包括开发广泛的可调谐纳米材料网络，以在单层纳米材料水平上定制能量转换特性，并在用于诊断传感、生物标志物识别的节能生物芯片中具有潜在的转化应用和治疗药物输送。生命科学家、工程研究人员、研究生和本科生将在生物医学工程的关键新兴领域接受培训。技术：该项目的目标是为构建和评估不同的高度灵活和适形的多层压电聚合物器件奠定基础，以转换机械将心脏位移转化为电能。虽然患有充血性心力衰竭的植入式心脏除颤器 (ICD) 患者的平均寿命已增加到植入后 10 年，但自动植入式心脏除颤器 (AICD) 的电池通常需要每 4-5 年更换一次，具体取决于严重程度起搏和/或除颤的发生。由于更换电池需要进行手术，这种不匹配造成了严重且不断增加的临床和经济负担。延长 AICD 电池寿命的创新解决方案是利用心脏的强大能量并将其转换为电能。该提案的假设是，在两个表面和整个体积上都含有介孔结构的柔性且适形的聚偏二氟乙烯 (PVDF) 聚合物薄膜可以嵌入 AICD 导线当前的死腔内，以转换心脏的机械运动利用PVDF的压电性将其转化为电能。研究方法包括： 1. 设计由多孔 PVDF 层制成的柔性微发电机，可与当前 AICD 领先技术接口； 2. 开发基于3D RV心脏运动的心脏发电装置的计算模型，以实现最佳设计和功率效率； 3. 发电机机电耦合的体外量化呈现给 AICD 引线。