Mesoporous PVDF Thin Film Device for Implantable Cardiac Power Generation

用于植入式心脏发电的介孔 PVDF 薄膜器件

• 批准号: 1509369
• 负责人: Xiaojing Zhang
• 金额: $ 33.2万
• 依托单位: Dartmouth College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1509369&HistoricalAwards=false
• 关键词: Mesoporous; PVDF; Thin; Film; Device

Title: Mesoporous PVDF Thin Film Device for Implantable Cardiac Power GenerationGoals: The PI will design flexible porous polymer film power generators that convert cardiac motion into electricity to recharge implantable devices Nontechnical:Energy consumption and battery replacement are among the most challenging problems with permanently implanted biomedical devices. This research addresses the fundamental issues related to the creation of robust, scalable, energy-relevant nanomaterials and implantable microsystems that work with the extraordinary effectiveness of biomechanical motion and processes of the human heart. The potential benefits of the research in advancing the field include the development of a broad class of tunable nanomaterials networks to tailor energy conversion characteristics at the level of a single layer of nanomaterials, with potential translational applications in energy efficient biochips for diagnostic sensing, biomarker identification, and therapeutic drug delivery. Life scientists, engineering researchers, graduate and undergraduate students will be trained in key emerging areas of biomedical engineering.Technical:The objective of this project is to lay the foundation for constructing and evaluating different highly flexible and conformable multilayered piezoelectric polymer devices for converting the mechanical displacement of the heart into electrical energy. While the longevity of an average implantable cardiac defibrillators (ICD) patient with congestive heart failure has increased to 10 years after implantation, the battery for an automatic implantable cardiac defibrillators (AICD) needs to be replaced typically every 4-5 years depending on the degree of pacing and/or occurrence of defibrillation. This mismatch poses a significant and ever growing clinical and economic burden since replacing the battery requires a surgery. An innovative solution to increase AICD battery lifetimes is to harness the robust energy of the heart and convert it to electrical power. The hypothesis of this proposal is that flexible and conformable poly(vinylidene fluoride) (PVDF) polymer films containing mesoporous structures at both surfaces and throughout the bulk can be embedded inside the current dead spaces of the AICD leads to convert the mechanical motion of the heart into electrical energy by exploiting the piezoelectricity of PVDF. The research methods include: 1. Design flexible micro-power generators made of porous PVDF layers that can be interfaced with current AICD lead technology; 2. Develop computational model of cardiac power generation devices based on 3D RV heart motion to allow for optimal design and power efficiency; 3. In vitro quantification of mechano-electrical coupling of the power generator presents to an AICD lead.

标题：用于植入心脏发电目标的介孔PVDF薄膜设备：PI将设计灵活的多孔聚合物膜发电机，这些发电机将心脏运动转换为电力，以补给可植入的可植入可植入的设备非技术：替代和替换电池是永久植入生物医学设备的最具挑战性的问题之一。这项研究探讨了与稳健，可扩展性，可伸缩的纳米材料和可植入的微型系统有关的基本问题，这些问题与人类心脏的生物力学运动和过程的非凡有效性一起起作用。该研究在进行该领域的潜在好处包括开发一类可调的纳米材料网络，以在单层纳米材料的水平上调整能量转化特性，并在能源有效的生物芯片中进行诊断，生物标志物识别和治疗药物的能源生物芯片中的潜在转化应用。生命科学家，工程研究人员，研究生和本科生将在生物医学工程的关键领域进行培训。技术：该项目的目的是为构建和评估不同高度灵活且可符合的多层多层聚合物设备的基础奠定基础，以将心脏的机械化能量转化为电子能量。尽管植入后的充血性心力衰竭患者（ICD）患者的平均植入型心脏除颤器（ICD）的寿命已增加到10年，但通常需要每4 - 5年每4 - 5年更换一次自动植入心脏除颤器（AICD）的电池，具体取决于速度和/或除草性的程度。自从取代电池以来，这种不匹配会带来重大且不断增长的临床和经济负担。增加AICD电池寿命的创新解决方案是利用心脏的强大能量并将其转换为电力。 The hypothesis of this proposal is that flexible and conformable poly(vinylidene fluoride) (PVDF) polymer films containing mesoporous structures at both surfaces and throughout the bulk can be embedded inside the current dead spaces of the AICD leads to convert the mechanical motion of the heart into electrical energy by exploiting the piezoelectricity of PVDF.研究方法包括：1。设计灵活的微功能发电机，由多孔PVDF层制成，可以与当前的AICD铅技术连接； 2。基于3D RV心脏运动的心脏发电设备的计算模型，以实现最佳设计和功率效率； 3。在体外定量发电机的机械电气耦合呈现给AICD铅。