Aligned Core-Shell Piezoelectric Nanofibers based Pressure Sensors on Catheter

导管上基于对齐核壳压电纳米纤维的压力传感器

• 批准号: 1309686
• 负责人: Xiaojing Zhang
• 金额: $ 20万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1309686&HistoricalAwards=false
• 关键词: Aligned; Core; Shell; Piezoelectric; Nanofibers

The objective of this research is to develop a new class of miniaturized sensors-on-cathetertechnology through the integration of functional nanomaterials and flexible microsystems, forin situ blood pressure and flow monitoring with high sensitivity, fast recovery time andminimal invasiveness. In particular, we will develop highly aligned core-shell piezoelectricnanofibers based flexible thin film sensors patterned on catheter tips with dramaticallyreduced form factor, which are ready to be deployed in intra-vascular environment.Intellectual Merits: Real-time endovascular pressure measurement techniques are crucial to evaluate the hemodynamics, which indicates the physiological state of the cardiovascular system. We propose a paradigm shift in designing the endovascular pressure sensing technology, through developing thin film flexible sensing structures using nanoengineered piezoelectric polymers which can be integrated on catheters without consuming its internal lumen space. Broader Impact: Development of versatile microsensors with built-in nanostructures as the core sensing elements can profoundly revolutionize the catheter development. In addition, the technology generated from this research can be extended to develop a broad class of flexible, robust, and biocompatible sensing nanomaterials with emergent behavior that work with the extraordinary effectiveness to quantify the biological processes.

本研究的目的是通过功能纳米材料和柔性微系统的集成开发新型微型化导管传感器技术，用于高灵敏度、快恢复时间和微创的原位血压和流量监测。特别是，我们将开发高度对准的基于核壳压电纳米纤维的柔性薄膜传感器，其图案化在导管尖端上，形状因数显着减小，可部署在血管内环境中。 智力优点：实时血管内压力测量技术至关重要评估血流动力学，表明心血管系统的生理状态。我们提出了血管内压力传感技术设计的范式转变，通过使用纳米工程压电聚合物开发薄膜柔性传感结构，该结构可以集成在导管上而不消耗其内部管腔空间。更广泛的影响：开发以内置纳米结构作为核心传感元件的多功能微传感器可以深刻地改变导管的开发。此外，这项研究产生的技术可以扩展到开发一类广泛的灵活、坚固和生物相容性传感纳米材料，这些材料具有突发行为，可以非常有效地量化生物过程。