New Approaches to Site-Selective Fluorination

位点选择性氟化的新方法

基本信息

批准号：
1465131
负责人：
Thomas Lectka
金额：
$ 42万
依托单位：
Johns Hopkins University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2018-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1465131&HistoricalAwards=false
关键词：
New Approaches Site Selective Fluorination

项目摘要

AbstractIn this project funded by the Chemical Synthesis program of the Chemistry Division, Professor Thomas Lectka of Johns Hopkins University is developing new chemical methods focused on site-selective fluorination to produce chemically interesting products not easily accessible by other means. At Johns Hopkins, Professor Lectka, supervises a research group that contains predominately undergraduates. In addition, graduate students are participants in the K-12 educational outreach program and also the Chemistry Olympiad; in a separate program offered by Hopkins called LEAD, two grad students spend time mentoring inner-city Baltimore middle school students twice a week in science and math. In summary, the P.I. plans to continue a track record of educating underrepresented minority groups (especially African-American and Hispanic undergraduates) for the foreseeable future.Operational simplicity, low catalyst loadings (where applicable), mutual compatibility, mild conditions, and broad scope are the fundamental goals. The recent, widespread interest in fluorine chemistry stems primarily from the utility of fluorinated compounds as pharmaceuticals. Nearly one quarter of the top pharmaceuticals on the market contain fluorine, placing synthetic fluorination methods, particularly those amenable to late-stage functionalization, among the most valuable warheads in the arsenal of the medicinal chemist.

摘要该项目由化学部化学综合计划资助，约翰·霍普金斯大学的托马斯·莱克特卡（Thomas Lectka）教授正在开发针对现场脱氟化的新化学方法，以生产化学有趣的产品，无法通过其他方式轻松访问。在约翰·霍普金斯（Johns Hopkins），莱克特卡（Lectka）教授，监督一个主要的本科生的研究小组。此外，研究生是K-12教育外展计划的参与者，也是化学奥林匹克运动会的参与者；在霍普金斯（Hopkins）提供的另一项名为Lead的节目中，两名研究生每周两次指导巴尔的摩中学学生在科学和数学上进行两次指导。总而言之计划在可预见的未来继续教育代表性不足的少数群体（尤其是非裔美国人和西班牙裔本科生）的记录。运营的简单性，低催化剂负载（如果适用），相互兼容性，轻度兼容性，轻度条件和范围是广泛的范围。最近对氟化学的广泛兴趣主要源于氟化化合物作为药物的实用性。市场上近四分之一的高级药品中含有氟，构成了合成的氟化方法，尤其是那些可与晚期功能化的方法，是药物化学家库中最有价值的弹头之一。