Career: Catalytic, Enantioselective C-C Bond Forming Reactions of Imines

职业：亚胺的催化、对映选择性 C-C 键形成反应

• 批准号: 9874694
• 负责人: Thomas Lectka
• 金额: $ 27.2万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9874694&HistoricalAwards=false
• 关键词: Career; Catalytic; Enantioselective; Bond; Forming

Professor Leckta's multifaceted research efforts explore aspects of asymmetric transformations of imines. These include addition reactions of enol- and allylsilanes and ketene silyl acetals to imino esters catalyzed by chiral Lewis acids, asymmetric Staudinger and Baylis-Hillman reactions. Also, the development of novel catalysts based on diborane as a bifunctional Lewis acid and (bis)phosphine ligands is being pursued while incorporating computations to evaluate and possibly design useful catalytic species. Creating a bridge between the experimental and the theoretical is a hallmark of Professor Leckta'a teaching goals, with computational chemistry employed in the introductory as well as advanced aspects of his curriculum. Further, plans are being made to include high school teachers with one goal being to develop visual aids to pique the interest of high school students.With this CAREER award, the Synthetic Organic Program supports the research and teaching efforts of Dr. Thomas Leckta of Johns Hopkins University. Professor Leckta's research deals with new ways to make nitrogen-containing molecules called amines in such a way that the three- dimensional shape or chirality of the molecule is controlled. This is ever more important when designing the synthesis of biomolecules and drugs. Professor Leckta's teaching emphasizes the use of computers as a tool for predicting the outcome of chemical reactions before time is invested in actually trying the chemistry in the laboratory. An outreach program is being planned that will involve high school teachers and provide demonstrations of high-quality graphics and computations to high school students.

Leckta教授的多方面研究工作探讨了亚胺不对称转变的各个方面。 其中包括烯醇和烯丙基烷酸酯和酮甲硅烷基乙烯的添加反应对伊米诺酯，手性路易斯酸，不对称的staudinger和Baylis-Hillman反应。 同样，正在追求基于双二氨酸的新型催化剂作为双功能刘易斯酸和（BIS）磷酸配体的发展，同时纳入了计算以评估并可能设计有用的催化物种。 在实验和理论之间建立桥梁是Leckta'a教学目标教授的标志，其介绍性以及他的课程的高级方面都采用了计算化学。 此外，还制定了包括高中教师的计划，其目标是开发视觉辅助工具以引起高中生的兴趣。在此职业奖中，合成有机计划支持约翰·霍普金斯大学的托马斯·莱克塔（Thomas Leckta）博士的研究和教学工作。 Leckta教授的研究涉及新的方法，以使含氮分子称为胺的方法，以使分子的三维形状或手性得到控制。 当设计生物分子和药物的合成时，这越来越重要。 Leckta教授的教学强调使用计算机作为预测时间反应结果的工具，用于在实验室实际尝试化学反应之前。 正在计划进行一项外展计划，该计划将涉及高中教师，并向高中生提供高质量图形和计算的演示。