Activation of C-F Bonds by Aryl Carbocations

芳基碳阳离子活化 C-F 键

• 批准号: 9809433
• 负责人: Thomas Lectka
• 金额: $ 25万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9809433&HistoricalAwards=false
• 关键词: Activation; Bonds; Aryl; Carbocations

The focus of this research is to study C-F bond activation in solution using carbocation intermediates as electrophilic fluoride abstractors. Systems wherein fluoride shifts between carbon atoms and are reversible and spectroscopically characterizable will be studied and ions containing (C-F-C) bonds will be prepared. The carbocation mediated activation of C-F bonds in chlorofluorocarbons and perfluorocarbons will also be examined. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Thomas Lectka of the Department of Chemistry at Johns Hopkins University. Professor Lectka will focus his work on developing methods for achieving selective C-F bond activation. The project has potential impact for the better production of poly- and perfluorinated hydrocarbons, important commercial products.

这项研究的重点是使用碳定位中间体作为亲电氟化物摘要研究溶液中的C-F键激活。 将研究碳原子之间氟化物移动和可逆的系统，并且将研究含有离子（C-F-C）键的光谱特征。 还将检查碳定位介导的C-F键在氯氟化合物和全氟化合物中的激活。 有了这个奖项，有机和大分子化学计划正在支持约翰·霍普金斯大学化学系的Thomas Lectka博士的研究。 Lectka教授将把他的工作集中在开发选择性C-F键激活的方法上。 该项目对更好地生产多氟化烃，重要的商业产品具有潜在的影响。