Activation of C-F Bonds by Aryl Carbocations

芳基碳阳离子活化 C-F 键

• 批准号: 9809433
• 负责人: Thomas Lectka
• 金额: $ 25万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9809433&HistoricalAwards=false
• 关键词: Activation; Bonds; Aryl; Carbocations

The focus of this research is to study C-F bond activation in solution using carbocation intermediates as electrophilic fluoride abstractors. Systems wherein fluoride shifts between carbon atoms and are reversible and spectroscopically characterizable will be studied and ions containing (C-F-C) bonds will be prepared. The carbocation mediated activation of C-F bonds in chlorofluorocarbons and perfluorocarbons will also be examined. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Thomas Lectka of the Department of Chemistry at Johns Hopkins University. Professor Lectka will focus his work on developing methods for achieving selective C-F bond activation. The project has potential impact for the better production of poly- and perfluorinated hydrocarbons, important commercial products.

本研究的重点是使用碳阳离子中间体作为亲电子氟化物吸收剂来研究溶液中 C-F 键的活化。 将研究氟化物在碳原子之间移动且可逆且可光谱表征的系统，并制备含有（C-F-C）键的离子。 还将检查氯氟烃和全氟化碳中碳正离子介导的 C-F 键活化。 有机和高分子化学项目通过该奖项支持约翰·霍普金斯大学化学系的 Thomas Lectka 博士的研究。 Lectka 教授的工作重点是开发实现选择性 C-F 键激活的方法。 该项目对于更好地生产重要商业产品多氟化碳氢化合物和全氟化碳氢化合物具有潜在影响。