Metal-mediated Cycloaromatizations of Acyclic Tri(pi) Conjugated Molecules

金属介导的无环三(π)共轭分子的环芳构化

基本信息

批准号：
1465079
负责人：
Joseph O'Connor
金额：
$ 48万
依托单位：
University of California-San Diego
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1465079&HistoricalAwards=false
关键词：
Metal mediated Cycloaromatizations Acyclic Tri

项目摘要

With this award, the Chemical Structure, Dynamics and Mechanisms B Program is supporting Professor Joseph M. O'Connor at the University of California-San Diego to examine the interaction of metals with readily available polyunsaturated organic compounds in order to understand the relationship between metal-coordination mode and chemical reactivity. These investigations afford opportunities for the development of new methods for the environmentally benign construction of molecules with useful properties of interest to the chemical and pharmaceutical industry. Professor O'Connor will integrate the research and educational components of this project in order to promote education in the STEM fields by providing interdisciplinary research opportunities for college and graduate students. The proposed chemistry is expected to advance fundamental understanding of organometallic, organic, and inorganic processes.In this research, a combination of synthetic, structural, computational and mechanistic studies will be applied to the development of new cycloaromatization reactions based on the metal-triggered reactions of acyclic tri(pi) conjugated molecules, including dienynes, trienes, and heteroatom-containing analogues. A key component of this research is the synthesis and study of hexahapto coordination of tri(pi) molecules to transition metals. These new reactions may have broad application in organic synthesis by providing alternatives to thermal pericyclic reactions.

通过此奖项，化学结构，动力学和机制B计划支持加利福尼亚大学山羊大学的约瑟夫·M·奥康纳教授，以研究金属与随时可用的多不饱和有机化合物的相互作用，以了解金属配任模式与化学反应性之间的关系。这些调查为开发新方法提供了机会，用于在化学和制药行业具有有用特性的分子的环境良性结构。 O'Connor教授将通过为大学和研究生提供跨学科研究机会来促进该项目的研究和教育组成部分，以促进STEM领域的教育。 The proposed chemistry is expected to advance fundamental understanding of organometallic, organic, and inorganic processes.In this research, a combination of synthetic, structural, computational and mechanistic studies will be applied to the development of new cycloaromatization reactions based on the metal-triggered reactions of acyclic tri(pi) conjugated molecules, including dienynes, trienes, and heteroatom-containing类似物。这项研究的一个关键组成部分是将三（PI）分子与过渡金属的六哈托协调合成和研究。这些新反应可能通过提供热周期反应的替代方法在有机合成中广泛应用。