Chemistry at the Alkyne - Carbene Intersection

炔烃-卡宾交叉点的化学

• 批准号: 1214024
• 负责人: Joseph O'Connor
• 金额: $ 49.7万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1214024&HistoricalAwards=false
• 关键词: Chemistry; Alkyne; Carbene; Intersection

With the support of an award from the Chemical Structure, Dynamics and Mechanism Program (CSDM) at the National Science Foundation, Professor Joseph M. O'Connor of the University of California, San Diego will lead a research program that will investigate the chemistry of metallacyclobutene and vinylcarbene complexes. Such complexes have been widely proposed as intermediates or transition state structures in metal-catalyzed reactions that impact the fields of organic synthesis, polymer chemistry, pharmaceuticals, material science and theory. The approach will involve a combination of synthetic, structural, computational and mechanistic work. Targeted molecules are chosen to maximize the potential for subsequent reactivity and to reveal mechanistic features of new and existing chemical transformations. The proposed chemistry will advance the fundamental knowledge base of organic, inorganic, and organometallic processes, and contribute to future advances in the environmentally friendly construction of molecules with useful properties. A key objective of the proposed studies it the interdisciplinary training of graduate students in the area of organometallic chemistry which will position them to make important scientific contributions to both industrial and academic endeavors.

在国家科学基金会的化学结构，动力学和机制计划（CSDM）奖励的支持下，加利福尼亚大学的约瑟夫·M·奥康纳教授将领导一项研究计划，该计划将研究金属酰基丁烯和乙烯基苯乙烯综合体的化学。 这种复合物已被广泛提出为金属催化反应中的中间体或过渡状态结构，影响有机合成，聚合物化学，药物，材料科学和理论领域。 该方法将涉及合成，结构，计算和机械工作的结合。 选择靶向分子以最大程度地提高反应性的潜力，并揭示新的和现有的化学转化的机械特征。 拟议的化学将推进有机，无机和有机化过程的基本知识基础，并为具有有用特性的分子的环境友好构建的未来进步做出了贡献。 拟议研究的主要目标是对有机金属化学领域的研究生的跨学科培训，这将使他们为工业和学术努力做出重要的科学贡献。