Metal-Coordinated Biradicals as Synthetic Intermediates

作为合成中间体的金属配位双自由基

• 批准号: 0616576
• 负责人: Joseph O'Connor
• 金额: $ 44.4万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0616576&HistoricalAwards=false
• 关键词: Metal; Coordinated; Biradicals; Synthetic; Intermediates

This project is focused on the development of fundamentally new synthetic methodology based on the intermediacy of novel metal-coordinated biradicals. Mechanistic and computational studies are to be employed in order to understand recently discovered metal-catalyzed Bergman cycloaromatization reactions. A single metal center will be employed to induce the formation of biradicals, transmit stereochemical information to remote bond-forming locations, and activate adjacent aromatic rings for subsequent stereoselective functionalization. Studies will also include the development of metal-triggered hetero-Bergman cycloaromatization reactions for the formation of heterocyclic compounds of synthetic importance. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Joseph M. O'Connor of the Department of Chemistry at University of California-San Diego. Professor O'Connor's research efforts revolve around the development of new synthetic methodology based on novel metal-coordinated biradicals. Such metal-coordinated biradicals offer promise for efficient approaches for the synthesis of complex organic molecules as well as the preparation of molecules that are virtually inaccessible in the absence of such radicals.

该项目的重点是基于新型金属协调的Biradicals的中间人的根本新的合成方法论的发展。 为了理解最近发现的金属催化的伯格曼环氧化反应反应的机械和计算研究。 将采用单个金属中心来诱导Biradicals的形成，将立体化学信息传输到远程键合的位置，并激活相邻的芳族环，以进行随后的立体选择性功能化。 研究还将包括为形成合成重要性的杂环化合物形成金属触发的杂种环形组合反应的发展。有了这个奖项，有机和大分子化学计划正在支持加利福尼亚大学山羊大学化学系约瑟夫·M·奥康纳教授的研究。 奥康纳教授的研究工作围绕着基于新型金属协调的Biradicals的新合成方法的发展。 这种金属协调的Biradicals为合成复杂的有机分子的合成以及在没有这种自由基的情况下几乎无法访问的分子的制备提供了有望的有望。