SBIR Phase II: Development of a Lens Replacement Device that Provides Enhanced Visual Acuity.

SBIR 第二阶段：开发可提供增强视力的晶状体替换设备。

• 批准号: 1430465
• 负责人: Paul Beer
• 金额: $ 75万
• 依托单位: Z Lens LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-10-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1430465&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Development; Lens

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to provide enhanced vision for patients after cataract surgery. Current devices, called intraocular lenses (IOLs), can correct certain vision problems. However, commercially available IOLs do not provide the same restoration of capabilities as other surgeries, such as hip replacements. In particular, current IOLs do not address the problems of presbyopia which is the continual degradation of the ability to change focus from far to near object which eventually results in the need for reading glasses. Devices that attempt to address presbyopia, but fail, represent a $500MM current market. This project has a novel approach to the problem and the opportunity to positively affect the lives of the 3 million people each year that are undergoing cataract surgery.The proposed project will continue to push the bounds of our understanding of the mechanisms of human vision control. Previous work done to measure the forces in the eye used to change vision from near to far objects, will be utilized in the design and testing of an IOL that can truly provide changes in vision like the normal lens of a 30 year old human. Several iterations of design will be tested in a rhesus monkey model to determine the best way to capture the forces in the eye, the optimal design of the shape of the device and materials used, the choice of optic material, and the procedures to insert and activate the IOL. All with the objective to turn currently available forces in the eye into refractive changes in eyesight. The ultimate goal of this project is to have a design that can be used for an FDA application for human clinical trials.

这项小型企业创新研究（SBIR）II期项目的更广泛的影响/商业潜力是为白内障手术后的患者提供增强的视力。 当前称为人眼镜（IOL）的设备可以纠正某些视力问题。 但是，市售的IOL不提供与其他手术（例如髋关节置换）相同的功能恢复。 特别是，当前的IOL并未解决长老会的问题，这是将重点从远到近对象变化的能力的持续退化，这最终导致需要阅读眼镜。 试图解决长老会但失败的设备代表了当前500mm的市场。 该项目对问题有一种新颖的方法，并有机会积极影响正在接受白内障手术的300万人的生活。拟议的项目将继续推动我们对人类视力控制机制的理解的界限。 以前的工作是为了测量用来改变视力从远到远的物体的力量，将用于设计和测试IOL的设计和测试，该IOL可以真正提供视力变化，例如30岁的人的正常镜头。 设计的几个迭代将在恒河猴模型中进行测试，以确定捕获眼睛中力的最佳方法，所使用的设备形状和所使用材料的最佳设计，光学材料的选择以及插入和激活IOL的程序。 所有这些目标都是将目前可用的力量转化为视力变化的。 该项目的最终目标是具有可用于人类临床试验应用程序的设计。