Interlocked fullerene and endohedral metallofullerene hosts for molecular machine-like sensing

用于分子机器传感的互锁富勒烯和内嵌金属富勒烯主体

基本信息

批准号：
EP/P033490/1
负责人：
Paul Beer
金额：
$ 111.58万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FP033490%2F1
关键词：
Interlocked fullerene endohedral metallofullerene hosts

项目摘要

Mechanically interlocked molecules such as rotaxanes, which resemble a molecular abacus with rod-like molecules passing through one or more rings and catenanes, which are two or more interpenetrating rings, are firmly established entities in the field of nanoscale molecular machines because of their ability to undergo controlled and reversible molecular motion through changes in the relative positions of their constituent parts. The inherent dynamics of such molecules can be controlled by light, electrochemical and chemical-based stimuli. This proposal aims to exploit their unique topological interlocked host cavities to recognize guest molecules as a means of causing the ring component of a rotaxane or catenane to move from one position to another along an rod-like axle or larger ring component as a sophisticated means of sensing negatively charged species of biological, medical and environmental importance. Through the attachment of nanoscale 'light bulbs' including luminescent metal 'filaments' inside an all carbon sphere-like football, to specific positions on the ring and axle components, the switching on or off of the light bulb is designed to occur when a target negatively charged species is recognised and causes ring components to slide or shuttle from one station position to another. Such materials can be thought of as "molecular machine-like sensors".Coating these materials on to conducting and optically transparent surfaces will produce devices that will change colour and/or emit light and undergo electrochemical perturbation in response to the addition of a specific negatively charged substrate. Fundamentally, the project will add considerable volume to our understanding of how complex molecular architectures, designed to exhibit dynamic motion, respond when confined to the sorts of surfaces that will, ultimately, underpin their application.

机械互锁的分子，例如轮烷（类似于分子算盘，杆状分子穿过一个或多个环）和索烷（两个或多个互穿环），是纳米级分子机器领域中牢固确立的实体，因为它们能够通过改变其组成部分的相对位置来进行受控和可逆的分子运动。这种分子的固有动力学可以通过光、电化学和化学刺激来控制。该提案旨在利用其独特的拓扑互锁主体空腔来识别客体分子，作为导致轮烷或索烷的环组分沿着杆状轴或更大的环组分从一个位置移动到另一个位置的一种手段，作为一种复杂的手段感测具有生物、医学和环境重要性的带负电荷的物种。通过将纳米级“灯泡”（包括全碳球状足球内的发光金属“灯丝”）连接到环和轴部件上的特定位置，灯泡的打开或关闭被设计为当目标出现时发生带负电的物质被识别并导致环部件从一个位置滑动或穿梭到另一个位置。这种材料可以被认为是“类似分子机器的传感器”。将这些材料涂覆到导电和光学透明的表面上将产生能够改变颜色和/或发光并响应于添加特定负电荷而经历电化学扰动的装置。带电底物。从根本上说，该项目将极大地加深我们对复杂分子结构（旨在展示动态运动）在限制于最终支撑其应用的各种表面时如何响应的理解。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Engineered Binding Microenvironments in Halogen Bonding Polymers for Enhanced Anion Sensing

用于增强阴离子传感的卤素键合聚合物中的工程结合微环境

DOI：
10.1002/ange.202300867
发表时间：
2023
期刊：
Angewandte Chemie
影响因子：
0
作者：
Bak K
通讯作者：
Bak K

Fullerene-Functionalized Halogen-Bonding Heteroditopic Hosts for Ion-Pair Recognition.

DOI：
10.1021/jacs.3c07774
发表时间：
2023-12-20
期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子：
15
作者：
Bak, Krzysztof M.;Marques, Igor;Kuhn, Heike;Christensen, Kirsten E.;Felix, Vitor;Beer, Paul D.
通讯作者：
Beer, Paul D.

Exploiting the mechanical bond for molecular recognition and sensing of charged species