Heteroditopic Calixarene Based Receptors for Ion Pair Recognition and Mechanical Bond Assembly

用于离子对识别和机械键组装的异双位杯芳烃受体

基本信息

批准号：
EP/E033962/1
负责人：
Paul Beer
金额：
$ 55.19万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FE033962%2F1
关键词：
Heteroditopic Calixarene Based Receptors Ion

项目摘要

This project aims to construct novel cyclic and interlocked 'host' molecules that are designed to simultaneously bind positively and negatively charged guest species within a single molecular host framework. Such multiple recognition site receptor systems have an exciting variety of potential uses as new extraction and membrane transport agents as well as having nanotechnological applications in sensing, switching and molecular machine-like behaviour.Using the 'bucket shaped' calix[4]arene molecule as a molecular scaffold the project begins with the covalent attachment of various cation and anion binding motifs onto this molecular framework to produce new cyclic heteroditopic receptors. Extensive inorganic ion-pair coordination studies will elucidate cooperative binding effects where a complexed cation will enhance the binding of an anion and vice-versa. Appropriately designed molecular cation-anion threading components, together with inorganic ion-pairs and neutral ligand threads will form interpenetrative assemblies with these ditopic host systems. Building on these pseudo-rotaxane assembly investigations, target interlocked chain-like catenane molecular structures will be synthesised using ion-pair templation synthetic methodologies and their ion-pair binding properties and chemically or electrochemically induced switchable rotational molecular movement investigated. The surface assembly of these interlocked catenane systems will lead to novel interfaces whose chemical characteristics may be modulated by switchable chemical and/or electrochemical control where rotational molecular movement exposes hydrophilic charged and hydrophobic neutral groups of the surface confined catenane systems. An attempt will be made to drive ( write ) this switching at molecular scales of spatial resolution and to subsequently read induced changes by proximal probe methods.

该项目旨在构建新型的环状和互锁的“宿主”分子，这些分子旨在在单个分子宿主框架内同时结合积极和负电荷的客人物种。这种多种识别位点受体系统具有令人兴奋的潜在用途，例如新的提取和膜传输剂，以及在感应，转换和类似于分子机器的行为中具有纳米技术的应用异地型受体。广泛的无机离子对配位研究将阐明合作的结合效应，而复合阳离子将增强阴离子和副副体的结合。适当设计的分子阳离子阳离子螺纹组件以及无机离子对和中性配体螺纹将与这些坐骨宿主系统形成跨渗量组件。在这些伪鼠烷组装研究的基础上，将使用离子-PAIR模板合成方法及其离子对结合特性，并在化学或电化学上诱导的可转换旋转分子运动研究。这些互锁的catenane系统的表面组装将导致新的界面，其化学特性可以通过可切换的化学和/或电化学控制调节，其中旋转分子运动暴露于表面受限的链苯二甲烷系统的亲水性充电和疏水性中性基团。将尝试以空间分辨率的分子尺度驱动（写）此切换，并随后通过近端探针方法读取引起的变化。