MRI: Acquisition of Confocal Raman Microscope for the Enhancement of Research and Education at Iona College

MRI：购买共焦拉曼显微镜以加强爱奥纳学院的研究和教育

• 批准号: 1427705
• 负责人: Sunghee Lee
• 金额: $ 18.42万
• 依托单位: IONA UNIVERSITY
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1427705&HistoricalAwards=false
• 关键词: MRI; Acquisition; Confocal; Raman; Microscope

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program, Iona College will acquire an inverted confocal Raman microscope. A microscope, which combines a Raman spectrometer with a confocal optical microscope, provides qualitative and quantitative vibrational information for structural and molecular analysis of materials at both the microscopic and bulk level. By scanning across a sample with high spatial resolution it provides analytical information on a wide range of samples, including biological matrices. The acquisition will provide training to undergraduate students in the use of this modern analytical tool. It will strengthen research opportunities for students in STEP and CSTEP (Collegiate STEP) programs funded by New York State that encourage underrepresented groups and outreach activities to high school teachers and students.The acquistion is aimed at enhancing research and education at all levels, especially in areas such as (a) studying in-situ microdroplet crystallization; (b) designing nanoparticle intracellular probes and small-molecule delivery/detection devices and probing cellular uptake of the nanocomplexes in situ for synthesis of drug delivery vehicles; (c) elucidating fundamental biotoxicity mechanisms of type-2 alkenes via examination of intracellular tracking of various molecular indicators for prediction of the toxicity of environmental chemicals; and (d) characterizing copper nitrosyls compounds and mechanisms of nitrosylations and denitrosylations to develop denitrosylations and catalysis for environmental/biological applications.

通过主要研究仪器计划（MRI）的奖项和化学研究仪器计划的支持，爱奥娜学院将获得倒置的共聚焦拉曼显微镜。将拉曼光谱仪与共焦光学显微镜相结合的显微镜提供了定性和定量的振动信息，用于在显微镜和散装水平上对材料的结构和分子分析。通过扫描具有高空间分辨率的样品，它提供了有关广泛样品（包括生物矩阵）的分析信息。此次收购将为本科生提供这种现代分析工具的培训。它将为纽约州资助的Step and CSTEP（大学步骤）计划的学生加强研究机会，该计划鼓励代表性不足的群体和向高中教师和学生提供外展活动。该收购旨在增强各级研究和教育，尤其是在（（a）研究中（a）诸如（a）situ Microdroplet的领域； （b）设计纳米颗粒内探针和小分子递送/检测装置，并探测纳米复合物的细胞摄取，以原位合成药物递送车； （c）通过检查各种分子指标的细胞内跟踪来预测环境化学物质的毒性，阐明了2型烷烃的基本生物毒性机制； （d）表征亚硝基化铜化合物以及硝基化和非硝基化的机制，以开发脱硝基化和为环境/生物学应用催化。

项目成果

Ibuprofen and the Phosphatidylcholine Bilayer: Membrane Water Permeability in the Presence and Absence of Cholesterol

布洛芬和磷脂酰胆碱双层：存在和不存在胆固醇时的膜水渗透性

• DOI: 10.1021/acs.langmuir.0c03638
• 发表时间: 2021
• 期刊: Langmuir
• 影响因子: 3.9
• 作者: Wood, Megan;Morales, Michael;Miller, Elizabeth;Braziel, Samuel;Giancaspro, Joseph;Scollan, Patrick;Rosario, Juan;Gayapa, Alyssa;Krmic, Michael;Lee, Sunghee
• 通讯作者: Lee, Sunghee

Trans-Resveratrol Decreases Membrane Water Permeability: A Study of Cholesterol-Dependent Interactions

• DOI: 10.1007/s00232-022-00250-0
• 发表时间: 2022-06-24
• 期刊: JOURNAL OF MEMBRANE BIOLOGY
• 影响因子: 2.4
• 作者: Ceja-Vega, Jasmin;Perez, Escarlin;Lee, Sunghee
• 通讯作者: Lee, Sunghee

Differential Effects of Soy Isoflavones on the Biophysical Properties of Model Membranes

• DOI: 10.1021/acs.jpcb.3c08390
• 发表时间: 2024-02-28
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY B
• 影响因子: 3.3
• 作者: Gudyka，Jamie;Ceja-Vega，Jasmin;Lee，Sunghee
• 通讯作者: Lee，Sunghee