Microreaction Engineering of Aqueous Phase Metal Catalyzed Reactions

水相金属催化反应的微反应工程

• 批准号: 1264630
• 负责人: Ryan Hartman
• 金额: $ 35.38万
• 依托单位: University of Alabama Tuscaloosa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1264630&HistoricalAwards=false
• 关键词: Microreaction; Engineering; Aqueous; Phase; Metal

ABSTRACTPI: Hartman, Ryan L.Institutions: University of Alabama TuscaloosaProposal Number: 1264630Title: Microreaction Engineering of Aqueous Phase Metal Catalyzed ReactionsIntellectual Merit The use of water as a reaction solvent has the potential to impact the sustainable, continuous flow manufacturing of specialty chemicals. Successfully engineering such processes require the ability to overcome some challenges, including 1) management of the formation of solids as non-covalently bonded materials on reactor surfaces (e.g., scale deposition), 2) design of efficient catalysts using understanding of the fundamental mechanisms that govern synthetic transformations, 3) innovation of novel reactors that efficiently couple the aromatics that make-up intermediates in fine chemical production, and 4) integration of analytics with laboratory synthesis tools for online reaction discovery and optimization. This research will address each of these four challenges. The PIs plan the engineering and integration of microreactors with confocal Raman microscopy, where the intrinsic kinetic and mechanistic knowledge of palladium-catalyzed C-H functionalization reactions with hydrophilic ligands will be made available in the absence of transport limitations. The use of hydrophilic ligands, and hence water as a reaction solvent, in fine chemical manufacturing presents the opportunity for greener pathways to useful compounds. The PIs will combine reactor design principles, analytical chemistry, and synthetic methodologies aimed at developing a platform, which can be used to continuously synthesize fine chemical intermediates with water as a reaction solvent. The enabling technology will combine concepts of (i) microreactor technology, (ii) the design of hydrophilic ligands for synthetic organic reactions, (iii) non-invasive analytical techniques for reaction monitoring, and (iv) multi-step microchemical synthesis involving reactions and separations. If successful, the knowledge generated will foster a new paradigm of sustainable chemical process design: the use of water as a solvent to manufacture fine chemicals.Broader Impacts This research seeks to establish fundamental understanding of reactor and process design of synthetic pathways that utilize water as a solvent. This understanding will advance chemical processes that synthesize specialty chemicals, in a sustainable way. Undergraduate and graduate students will benefit from this work through the evolution of the reaction engineering curricula and undergraduate research opportunities for underrepresented groups. Furthermore, students K-12+ will be engaged by the creation of online YouTube videos through an undergraduate competition between the University of Southern California and the University of Alabama aimed at the interfacing of advanced chemistry and reactor design concepts, real world engineering problems, and pop culture. The work will also expose graduate students to international research experiences through collaboration with the Institute of Condensed Matter Chemistry Bordeaux (ICMCB). These educational components will strengthen the undergraduate engineering education at the University of Alabama, foster early interest in engineering careers from K-12 students, and provide unique opportunities for graduate students to gain international exposure.

摘要：Hartman, Ryan L.机构：阿拉巴马大学塔斯卡卢萨分校提案编号：1264630标题：水相金属催化反应的微反应工程智力价值使用水作为反应溶剂有可能影响特种化学品的可持续、连续流动制造。成功设计此类工艺需要能够克服一些挑战，包括 1) 管理反应器表面非共价键合材料固体的形成（例如结垢沉积），2) 通过了解基本机制设计高效催化剂控制合成转化，3）新型反应器的创新，可有效耦合构成精细化工生产中间体的芳族化合物，以及4）将分析与实验室合成工具集成，以进行在线反应发现和优化。这项研究将解决这四个挑战。 PI 计划对微反应器与共焦拉曼显微镜进行工程设计和集成，其中钯催化的 C-H 官能化反应与亲水配体的内在动力学和机理知识将在没有传输限制的情况下提供。在精细化学品制造中使用亲水性配体以及水作为反应溶剂为获得有用化合物的更绿色途径提供了机会。 PI将结合反应器设计原理、分析化学和合成方法，旨在开发一个平台，可用于以水为反应溶剂连续合成精细化工中间体。该技术将结合以下概念：（i）微反应器技术，（ii）用于合成有机反应的亲水配体的设计，（iii）用于反应监测的非侵入性分析技术，以及（iv）涉及反应和反应的多步微化学合成。分离。如果成功，所产生的知识将培育可持续化学工艺设计的新范式：使用水作为溶剂来制造精细化学品。 更广泛的影响 这项研究旨在建立对反应器和利用水作为合成途径的工艺设计的基本理解。溶剂。这种理解将以可持续的方式推进合成特种化学品的化学工艺。通过反应工程课程的发展和针对代表性不足群体的本科生研究机会，本科生和研究生将从这项工作中受益。此外，K-12+ 学生将通过南加州大学和阿拉巴马大学之间的本科生竞赛参与制作在线 YouTube 视频，该竞赛旨在将先进化学和反应器设计概念、现实世界的工程问题以及流行文化。这项工作还将通过与波尔多凝聚态化学研究所（ICMCB）的合作，让研究生接触到国际研究经验。这些教育内容将加强阿拉巴马大学的本科工程教育，培养 K-12 学生对工程职业的早期兴趣，并为研究生提供获得国际视野的独特机会。