Collaborative Research: Photonic and Electronic Devices Based on Self-Assembling DNA Templates

合作研究：基于自组装DNA模板的光子和电子器件

• 批准号: 1232239
• 负责人: Gleb Finkelstein
• 金额: $ 22.5万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1232239&HistoricalAwards=false
• 关键词: Collaborative; Research; Photonic; Electronic; Devices

The objective of this program is to develop reliable protocols for fabricating functional photonic and electronic nanostructures using bioinspired, molecular assembly methods. In one of the proposed tasks, seed nanoparticles will be selectively attached through molecular recognition to the ?DNA origami? template and fused to form the electrodes; a separate nanoparticle island will be separately attached forming a single-electron transistor. In the other major task, plasmonic bow-tie antennae will be assembled from nanoparticles, and the optically active nanoscale object will be attached in the hot spot. The intellectual merit of the proposed project stems from the convergence of recent advances in DNA-based self-assembly methods with promising preliminary results on specific surface binding of solution-assembled complexes. These nanostructures may develop into a new class of naturally biocompatible sensors that will have transformative applications in the biomedical field. The broader impacts are the development of alternative, cheaper (most steps are in aqueous solution) and more versatile fabrication methods for making composite bio-nano-devices. The proposal has a strongly emphasized outreach component: the PIs plan to recruit MSc students from the North Carolina Central University ? a historically black university (HBCU). The program will train the students in the unique combination of biochemical and physical methods of modern nanotechnology that are relevant for both industrial and academic careers. Disadvantaged high school students (Project SEED) will participate during the summer months to get a feel for the emerging field of nanoscience.

该计划的目标是开发可靠的协议，使用仿生分子组装方法制造功能性光子和电子纳米结构。在提议的任务之一中，种子纳米颗粒将通过分子识别选择性地附着到“DNA折纸”上。模板并熔合形成电极；一个单独的纳米颗粒岛将被单独连接形成一个单电子晶体管。在另一项主要任务中，等离子体领结天线将由纳米颗粒组装而成，并且光学活性纳米级物体将附着在热点中。该项目的智力价值源于基于 DNA 的自组装方法的最新进展与溶液组装复合物的特定表面结合的有希望的初步结果的融合。这些纳米结构可能会发展成为一类新型的天然生物相容性传感器，在生物医学领域具有革命性的应用。更广泛的影响是开发替代性的、更便宜的（大多数步骤是在水溶液中）和更通用的制造方法来制造复合生物纳米器件。该提案有一个重点强调的外展部分：PI 计划从北卡罗来纳中央大学招收理学硕士学生？一所历史悠久的黑人大学（HBCU）。该计划将培训学生现代纳米技术生物化学和物理方法的独特结合，这些方法与工业和学术职业相关。弱势高中生（SEED 项目）将在夏季参加，以感受新兴的纳米科学领域。