Separation of mixtures of chiral volatile anestethics via modified porous glasses

通过改性多孔玻璃分离手性挥发性麻醉剂混合物

基本信息

批准号：
206088065
负责人：
Professor Dr.-Ing. Andreas Seidel-Morgenstern
金额：
--
依托单位：
Max-Planck-Institut für Dynamik komplexer technischer Systeme
依托单位国家：
德国
项目类别：
Priority Programmes
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/206088065?language=en
关键词：
Separation mixtures chiral volatile anestethics

项目摘要

The separation of racemic mixture of fluranes applied as anaesthetic gases is of large interest, since the specific effects of the individual enantiomers is not sufficiently known. Corresponding investigations are still hampered due to the limited availability of the corresponding pure enantiomers.In the first period of this project glass beads of various pore and particle sizes were synthesized. It was possible to immobilize suitable cyclodextrin-based selectors on the surface of these beads and to perform first successful enantioseparations.In the currently ongoing funding period the synthesis of the supports has been improved further. Glass beads in which the pore structure was altered by pseudomorphic transformation were synthesized exhibiting already functionalized surfaces. The synthesis was reproducible and larger amounts of samples could be provided for chromatographic investigations. In comparison to the pathway used in the first period, the fixation of the enantioselective selector could be further improved allowing for better separation results. A more detailed characterization regarding the intraparticle mass transport of chiral molecules was performed exploiting IR micro-imaging. Adsorption capacities and separation factors were determined analyzing results of chromatographic column overloading experiments. A simplified mathematical model, which is capable to describe and optimize the chromatographic columns filled with the prepared particles, was developed and applied to estimate the productivity of the separation for columns with larger diameters.The production of pure enantiomers is in the focus of the third funding period. Larger column dimensions and an improved experimental set-up should be used. The enantiomers leaving the separation column should be subsequently captured in an adsorber before desorbing and condensing them. It is further planned to test the applicability of the model developed with respect to predict the separation process occurring in larger columns over a wider parameter range. An anticipated extension of the model will be realized by incorporating available transport parameters. In addition, it is planned in the third period to perform orienting small scale experiments with new particles of larger diameter and with core-shell-particles. These new supports are potentially advantageous for later separations in an even larger scale.

由于单个对映异构体的特定作用尚不清楚，因此将氟兰氏氟烷的外消旋混合物的分离引起了人们的关注。由于相应的纯对映异构体的可用性有限。可以将合适的基于环糊精的选择器固定在这些珠子的表面上，并首先执行成功的对映射。合成已经具有功能化的表面的玻璃珠，通过伪形变化改变了孔结构。该合成是可重现的，可以提供大量样品进行色谱研究。与第一阶段使用的途径相比，可以进一步改善对映选择性选择器的固定，从而获得更好的分离结果。对手性分子的颗粒内质量转运进行了更详细的表征，以利用IR微型成像。确定了吸附能力和分离因子，以分析色谱柱过载实验的结果。开发并应用了一个简化的数学模型，该模型能够描述和优化带有准备好的粒子的色谱柱，并应用于估计较大直径的柱的分离生产率。纯对映异构体的产生是第三融资期的重点。应使用较大的色谱柱尺寸和改进的实验设置。离开分离柱的对映异构体随后应在吸附者中捕获并凝结它们。进一步计划测试开发的模型的适用性，以预测在较大参数范围内较大列中发生的分离过程。该模型的预期扩展将通过合并可用的传输参数来实现。此外，计划在第三阶段，以较大直径和核心壳粒子的新粒子进行定向小尺度实验。这些新的支持对于以后在更大规模的以后分离可能是有利的。