Routes to UV Activated Fouling Reversal and Molecular Weight Cutoff Control in Tethered Micelle Ultrafiltration Membrane Assemblies

系留胶束超滤膜组件中紫外线激活污垢逆转和分子量截留控制的途径

• 批准号: 1160026
• 负责人: Travis Bailey
• 金额: $ 40万
• 依托单位: Colorado State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1160026&HistoricalAwards=false
• 关键词: Routes; UV; Activated; Fouling; Reversal

1160026BaileyThis NSF award by the Chemical and Biological Separations program of the Chemical, Bionengineering, Environmental, and Transport Systems (CBET) Division and the Macromolecular, Supramolecular and Nanochemistry (MSN) Program of the Chemistry Division supports work by Professor Travis S. Bailey to develop new a new class of ultrafiltration membranes relevant to biological separations prevalent across a range of industries, particularly pharmaceutical processes involving antibody and protein based drug purification. In a recent article by Reuters published in April 2011, it was projected that as early as 2014, 8 of the 10 world?s top selling drugs will be antibody based biologics. Separations involving the manufacture of these biologics continue to represent a major fraction of the production cost, due to high costs of current membrane technologies (e.g. Protein A type columns), limited membrane lifetimes due to excessive fouling, and difficult integration into large scale purification process flows. In response to these fundamental challenges, this work explores a new approach to ultrafiltration membrane fabrication based on photoactive tethered micelle networks, assembled from nanostructured block copolymer assemblies. The principal objectives of the proposed research are to develop and validate the potential of this new class of ultrafiltration membranes to provide (1) high flux, (2) narrow and uniform pore size distributions, (3) user-enabled tuning of the molecular weight cutoff regimes and (4) built in fouling resistance and reversal capabilities. Cumulative energy (and therefore cost) savings associated with higher efficiency ultrafiltration processes would have worldwide impact, dramatically reducing purification processing costs associated with antibody and other protein based drugs being brought to market. Improved fouling resistance and effective reversal strategies would additionally extend the range of systems for which ultrafiltration is a viable separations solution.

1160026Bailey 这项由化学、生物工程、环境和运输系统 (CBET) 部门的化学和生物分离计划以及化学部门的大分子、超分子和纳米化学 (MSN) 计划颁发的 NSF 奖项支持 Travis S. Bailey 教授的工作，以开发新型超滤膜与广泛应用于多个行业的生物分离相关，特别是涉及抗体和蛋白质药物纯化的制药工艺。路透社在 2011 年 4 月发表的一篇文章中预计，最早到 2014 年，全球最畅销的 10 种药物中就有 8 种将是基于抗体的生物制剂。由于当前膜技术（例如 Protein A 型色谱柱）成本高昂、过度污染导致膜寿命有限以及难以集成到大规模纯化过程中，涉及这些生物制品制造的分离仍然占生产成本的主要部分流动。为了应对这些基本挑战，这项工作探索了一种基于光活性束缚胶束网络的超滤膜制造新方法，该网络由纳米结构嵌段共聚物组件组装而成。拟议研究的主要目标是开发和验证此类新型超滤膜的潜力，以提供（1）高通量，（2）狭窄且均匀的孔径分布，（3）用户可调节的分子量切断制度和（4）内置抗污垢和逆转能力。与更高效率的超滤工艺相关的累积能源（以及成本）节省将产生世界范围的影响，大大降低与抗体和其他基于蛋白质的药物推向市场相关的纯化处理成本。改进的抗污染性和有效的逆转策略将进一步扩大超滤作为可行分离解决方案的系统范围。