Organic Transformations with Dihapto-Coordinated Arene Complexes

双键配位芳烃配合物的有机转化

• 批准号: 1152803
• 负责人: Walter Harman
• 金额: $ 47万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1152803&HistoricalAwards=false
• 关键词: Organic; Transformations; Dihapto; Coordinated; Arene

Professor W. Dean Harman of the University of Virginia is supported by the Chemical Synthesis Program in the Division of Chemistry to conduct research that explores the ability of specially designed tungsten complexes, known as dearomatization agents, to coordinate and activate various types of aromatic molecules toward novel chemical transformations. The cornerstone of this approach is the implementation of highly pi-basic transition metal complexes that forms strong back-bonding interactions with the aromatic molecule. The research focuses on three areas: 1) the activation and manipulation of phenols and anilines 2) the activation and manipulation of polyaromatic hydrocarbons and 3) the development of enantio-enriched dearomatization agents that can be used for the synthesis of enantio-enriched organic products derived from aromatic molecules. These new methodologies will be used to generate new organic compounds that will be broad-screened for biological function and medicinal value.New synthetic methods that can convert ubiquitous aromatic molecules into highly functionalized molecules provide facile routes for the preparation of new synthetic substances not readily available from other methods. In most cases, these are entirely new compounds, and are of interest to the biochemical and medicinal communities as potential leads for the development of new biological probes and medicines. The project is highly interdisciplinary, combining elements of coordination chemistry, organometallics, organic, and medicinal chemistries. As a result, Ph. D. and undergraduate students involved with this research will receive the type of broad education required for them to be successful as modern synthetic chemists.

弗吉尼亚大学的W. Dean Harman教授得到了化学合成计划的支持，以探讨特殊设计的Tungsten复合物（称为Dearomatization剂）的能力，以协调和激活各种类型的芳族分子朝向新的化学化学转化。这种方法的基石是实施高度Pi-Basic转变金属络合物，该金属复合物与芳香族分子形成强大的后键相互作用。该研究侧重于三个领域：1）苯酚和苯胺的激活和操纵2）多芳族烃的激活和操纵； 3）3）富含对映体富集的亲爱的剂的开发，可用于合成从芳香族分子中衍生的有机产物合成。 这些新方法将用于生成新的有机化合物，这些有机化合物将被广泛进行生物学功能和药用价值。新合成方法可以将无处不在的芳香族分子转换为高度功能的分子，为在其他方法中无法轻松获得的新合成物质提供可轻松的途径。 在大多数情况下，这些都是全新的化合物，并且对生化和药用群落的兴趣是开发新的生物探针和药物的潜在潜在客户。该项目是高度跨学科的，结合了协调化学，有机金属，有机化和药用化学的元素。 结果，参与这项研究的博士和本科生将获得他们作为现代合成化学家成功所需的广泛教育。