Organic Transformations with eta2-Arene Complexes

eta2-芳烃配合物的有机转化

• 批准号: 9212008
• 负责人: Walter Harman
• 金额: $ 24.46万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-15 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9212008&HistoricalAwards=false
• 关键词: Organic; Transformations; eta2; Arene; Complexes

Coordinated arenes can serve as valuable synthons to a variety of mono-and polycyclic natural products when used in conjunction with an appropriate dihapto-coordination agent. In order to test and develop this hypothesis, the research program will address three primary questions: i) what organic transformations can be accomplished through such a technology that are difficult to achieve by conventional methods, ii) to what extent can the stereochemistry of such transformations be controlled by the transition metal, and iii) how can the nature of the complexing agent be modified to achieve a) greater activation of the aromatic substrate b) asymmetric induction, and c) a catalytic cycle for various target reactions? %%% With this award, the Organic Synthesis Program will support the research of Dr. W. Dean Harman at the University of Virginia. The research will develop the reactions of coordinated arene transition metal complexes to form substituted cyclic products which has the effect of shortening certain synthetic sequences. This new synthetic methodology should benefit research in biochemistry and medicine as well as in the chemical industry.

当与适当的二茶配位剂结合使用时，协调的领域可以用作各种单一和多环天然产物的宝贵合成子。 In order to test and develop this hypothesis, the research program will address three primary questions: i) what organic transformations can be accomplished through such a technology that are difficult to achieve by conventional methods, ii) to what extent can the stereochemistry of such transformations be controlled by the transition metal, and iii) how can the nature of the complexing agent be modified to achieve a) greater activation of the aromatic substrate b) asymmetric induction, and c) a catalytic cycle对于各种目标反应？ 有机综合计划将获得该奖项的%%％，将支持弗吉尼亚大学W. Dean Harman博士的研究。 这项研究将开发协调的芳烃过渡金属复合物的反应，形成取代的环状产物，该循环产物具有缩短某些合成序列的作用。 这种新的合成方法学应受益于生物化学和医学以及化学工业的研究。