Organic Transformations with h2-Arene Complexes of Rhenium

铼的 h2-芳烃配合物的有机转化

• 批准号: 0111558
• 负责人: Walter Harman
• 金额: $ 36.9万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0111558&HistoricalAwards=false
• 关键词: Organic; Transformations; h2; Arene; Complexes

With the support of the Organic and Macromolecular Chemistry Program, Professor W. Dean Harman, of the Department of Chemistry at the University of Virginia, is studying organic transformations using eta-2 arene complexes of rhenium. Through the selective and reversible binding of arenes or polyaromatic hydrocarbons through dihapto coordination to a transition metal, their reactivity toward electrophiles is enhanced. Reactive intermediates (e.g., arenium and allyl cations) are stabilized, facilitating the assembly of polycyclic structures. In addition, metal coordination directs the stereochemistry of various chemical transformations and protects the coordination site for additional transformations. While dihapto coordination of arenes has previously been limited to pentaammineosmium(II) complexes, Professor Harman is developing a new class of rhenium(I)-based dearomatization agents.Aromatic compounds (e.g., benzene, toluene) represent one of the most readily available classes of compounds for elaboration into more complex molecular structures. However, their unique properties place some limitations on the chemical reactions available for their elaboration. Professor W. Dean Harman, of the Department of Chemistry at the University of Virginia, with the support of the Organic and Macromolecular Chemistry Program, is developing unique metal-based reagents which allow for the dramatic alteration of the reactivity of aromatic compounds. Through his studies, new methods are being developed allowing the facile and selective conversion of these readily available starting materials to compounds of potential significance in their own right or as intermediates in the synthesis of pharmaceuticals and other fine chemical products.

在有机和大​​分子化学计划的支持下，弗吉尼亚大学化学系的W. Dean Harman教授正在使用Rhenium的Eta-2 Arene Complexes研究有机转化。通过通过Dihapto协调到过渡金属的选择性和可逆的结合，它们对电力的反应性得到了增强。反应性中间体（例如，芳烃和烯丙基阳离子）稳定，促进了多环结构的组装。此外，金属协调指导各种化学转化的立体化学，并保护协调位点以进行其他转换。虽然竞技场的Dihapto协调限制在五症症状（II）复合体中，但Harman教授正在开发一种新的基于Rhenium（I）基于的（I）的亲爱的疗法剂。芳香族化合物（例如苯，苯，oluuene）代表了精心绘制的化合物之一，用于更复杂的化合物中，这是一种更复杂的化合物。但是，它们独特的特性对可用于阐述的化学反应有所限制。弗吉尼亚大学化学系的W. Dean Harman教授在有机和大​​分子化学计划的支持下，正在开发独特的基于金属的试剂，从而允许芳香族化合物反应性的急剧改变。通过他的研究，正在开发新的方法，使这些容易获得的起始材料可以轻松地转换为自己的权利或作为中间体的潜在意义的化合物。