Identification and functional characterization of causal genes affecting feather pecking and aggressive pecking in laying hens

影响蛋鸡啄羽和攻击性啄羽的致病基因的鉴定和功能表征

基本信息

批准号：
202423786
负责人：
Professor Dr. Jörn Bennewitz
金额：
--
依托单位：
Fachgebiet Genetik und Züchtung landwirtschaftlicher Nutztiere (460g)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2021-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/202423786?language=en
关键词：
Identification functional characterization causal genes

项目摘要

Feather pecking and cannibalism are serious problems poultry production. They have not only negative economic and environmental implications, but also represents a serious welfare problem. The aims of a recent project were to obtain a deeper understanding of ethological and genetic mechanisms of feather pecking. In that project a large experimental population consisting of about 950 F2-cross laying hens was established and characterized phenotypically for a wide range of behavior traits. The trait interrelation structure was investigated by correlation analyses as well as non-parametric statistics. In addition, the individuals were genotyped for a 60K SNP-chip and these data were used for genome-wide association analyses. Several pecking behavior associated chromosomal clusters were identified. The follow-on project is designed as an in-depth analysis of these chromosomal clusters. The overall aim is to derive and validate (novel) hypotheses with regard to feather pecking and aggressive pecking behavior in laying hens by means of mapping and functional analyses of causal genes affecting these traits. With these aims the project contributes to the genetic dissection of pecking behavior in laying hens and to a better understanding of the motivation for these abnormal behavior patterns. Further, it contributes to the goals of the precision animal breeding framework, which is urgently needed, because feather pecking will be an integral part of laying hen breeding goals soon.

羽毛啄食和食人主义是家禽生产的严重问题。他们不仅具有负面的经济和环境影响，而且还代表了一个严重的福利问题。最近一个项目的目的是获得对羽毛啄食的伦理学和遗传机制的更深入的了解。在该项目中，建立了由约950个F2跨性母鸡组成的大型实验人群，并针对广泛的行为特征进行表型表征。通过相关分析以及非参数统计数据研究了性状相互关系结构。此外，将个体用于60k SNP-CHIP，并将这些数据用于全基因组关联分析。确定了几种相关的染色体簇。后续项目被设计为对这些染色体簇的深入分析。总体目的是通过对影响这些特征的因果基因的映射和功能分析来得出关于羽毛啄食和侵略性啄食行为的（新颖）假设。通过这些目标，该项目有助于啄食母鸡的啄食行为的遗传解剖，并更好地理解这些异常行为模式的动机。此外，这迫切需要精确的动物育种框架的目标，因为羽毛啄食将是奠定母鸡育种目标不可或缺的一部分。