Identification and functional characterization of causal genes affecting feather pecking and aggressive pecking in laying hens

影响蛋鸡啄羽和攻击性啄羽的致病基因的鉴定和功能表征

• 批准号: 202423786
• 负责人: Professor Dr. Jörn Bennewitz
• 金额: --
• 依托单位: Fachgebiet Genetik und Züchtung landwirtschaftlicher Nutztiere (460g)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/202423786?language=en
• 关键词: Identification; functional; characterization; causal; genes

Feather pecking and cannibalism are serious problems poultry production. They have not only negative economic and environmental implications, but also represents a serious welfare problem. The aims of a recent project were to obtain a deeper understanding of ethological and genetic mechanisms of feather pecking. In that project a large experimental population consisting of about 950 F2-cross laying hens was established and characterized phenotypically for a wide range of behavior traits. The trait interrelation structure was investigated by correlation analyses as well as non-parametric statistics. In addition, the individuals were genotyped for a 60K SNP-chip and these data were used for genome-wide association analyses. Several pecking behavior associated chromosomal clusters were identified. The follow-on project is designed as an in-depth analysis of these chromosomal clusters. The overall aim is to derive and validate (novel) hypotheses with regard to feather pecking and aggressive pecking behavior in laying hens by means of mapping and functional analyses of causal genes affecting these traits. With these aims the project contributes to the genetic dissection of pecking behavior in laying hens and to a better understanding of the motivation for these abnormal behavior patterns. Further, it contributes to the goals of the precision animal breeding framework, which is urgently needed, because feather pecking will be an integral part of laying hen breeding goals soon.

啄羽和同类相食是家禽生产中的严重问题。它们不仅对经济和环境产生负面影响，而且还带来严重的福利问题。最近的一个项目的目的是更深入地了解啄羽的行为学和遗传机制。在该项目中，建立了由约 950 只 F2 杂交蛋鸡组成的大型实验群体，并对其各种行为特征进行了表型表征。通过相关分析和非参数统计研究了特质相互关系结构。此外，还对个体进行了 60K SNP 芯片的基因分型，并将这些数据用于全基因组关联分析。鉴定了几种与染色体簇相关的啄食行为。后续项目旨在对这些染色体簇进行深入分析。总体目标是通过对影响这些性状的因果基因进行绘图和功能分析，得出并验证有关蛋鸡啄羽和攻击性啄食行为的（新）假设。出于这些目标，该项目有助于对蛋鸡啄食行为进行基因剖析，并有助于更好地理解这些异常行为模式的动机。此外，它还有助于实现迫切需要的精准动物育种框架的目标，因为啄羽很快将成为蛋鸡育种目标的一个组成部分。

项目成果

Genomewide Mapping of Selection Signatures and Genes for Extreme Feather Pecking in Two Divergently Selected Laying Hen Lines

两个不同选择的蛋鸡品系中极端啄羽行为的选择特征和基因的全基因组图谱

• DOI: 10.3390/ani10020262
• 发表时间: 2020
• 期刊: Animals : an Open Access Journal from MDPI
• 作者: Iffl; H.; R. Wellmann; M. Schmid; S. Preuß; J. Tetens; W. Bessei; J. Bennewitz
• 通讯作者: J. Bennewitz

Analysis of the brain transcriptome in lines of laying hens divergently selected for feather pecking

不同啄羽蛋鸡品系的脑转录组分析

• DOI: 10.1186/s12864-020-07002-1
• 发表时间: 2020-08-27
• 期刊: BMC Genomics
• 影响因子: 4.4
• 作者: C. Falker;Andrea Mott;S. Preuss;S. Franzenburg;W. Bessei;J. Bennewitz;J. Tetens
• 通讯作者: J. Tetens

A Novel Model to Explain Extreme Feather Pecking Behavior in Laying Hens

解释蛋鸡极端啄羽行为的新模型

• DOI: 10.1007/s10519-019-09971-w
• 发表时间: 2020
• 期刊: Behavior Genetics
• 影响因子: 2.6
• 作者: Iffl; H.; R. Wellmann; S. Preuß; J. Tetens; W. Bessei; H.
• 通讯作者: H.

Phenotypic and genomic analyses of agonistic interactions in laying hen lines divergently selected for feather pecking

不同啄羽蛋鸡品系竞争相互作用的表型和基因组分析

• DOI: 10.1016/j.applanim.2020.105177
• 发表时间: 2021
• 期刊: Applied Animal Behaviour Science
• 影响因子: 2.3
• 作者: Iffl; H.; M. Schmid; S. Preuß; W. Bessei; J. Tetens; J. Bennewitz
• 通讯作者: J. Bennewitz

Gut Microbial Composition and Predicted Functions Are Not Associated with Feather Pecking and Antagonistic Behavior in Laying Hens

肠道微生物组成和预测功能与蛋鸡啄羽和对抗行为无关

• DOI: 10.3390/life11030235
• 发表时间: 2021-03-12
• 期刊: Life
• 作者: Borda-Molina D;Iffland H;Schmid M;Müller R;Schad S;Seifert J;Tetens J;Bessei W;Bennewitz J;Camarinha-Silva A
• 通讯作者: Camarinha-Silva A