Arabidopsis 2010: Simultaneous Genome Wide Association Mapping in Plant Host and Pathogen

拟南芥 2010：植物宿主和病原体的同步全基因组关联作图

基本信息

批准号：
1021861
负责人：
Daniel Kliebenstein
金额：
$ 137.78万
依托单位：
University of California-Davis
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-15 至 2015-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1021861&HistoricalAwards=false
关键词：
Arabidopsis 2010 Simultaneous Genome Wide

项目摘要

Infectious disease has long been studied either via investigations into the pathogen or host. However, it is more appropriate to consider disease as the outcome of how the genomes from two organisms interact, especially for endemic diseases which cause significant and persistent losses in numerous economic arenas ranging from agriculture to business. This project will begin one of the first investigations into how the genetic diversity present in entire host and pathogen genomes simultaneously interact to control the infection outcome. Using next generation sequencing with a diverse and destructive plant pathogen, Botrytis cinerea (grey mold), and a model plant, Arabidopsis thaliana, this project will specifically identify diversity networks that enable an endemic plant disease to overcome diverse and fluctuating plant defenses. This will provide unique insight into how endemic diseases may evolve and provide ideas of how to counter this evolution. Additionally, this project will provide novel insights and guidance into how to conduct genome wide association studies on complex phenotypes such as disease. The project will involve a highly integrative combination of biology, genetics, biochemistry and computational genomics all within a single laboratory that will provide an optimal platform in which to train future scientists that can take full advantage of all genomic technologies to more efficiently solve societies pressing questions and problems.

长期以来，人们一直通过研究病原体或宿主来研究传染病。然而，将疾病视为两种生物体基因组相互作用的结果更为合适，特别是对于在从农业到商业等众多经济领域造成重大和持续损失的地方病。该项目将开始首批研究之一，研究整个宿主和病原体基因组中存在的遗传多样性如何同时相互作用以控制感染结果。该项目将利用下一代测序技术对多种破坏性植物病原体灰霉病（灰霉病）和模式植物拟南芥进行特异性鉴定，确定多样性网络，使地方性植物病能够克服多样化和波动性的植物防御。这将为地方病如何演变提供独特的见解，并提供如何应对这种演变的想法。此外，该项目将为如何对疾病等复杂表型进行全基因组关联研究提供新的见解和指导。该项目将在一个实验室内高度整合生物学、遗传学、生物化学和计算基因组学，这将提供一个最佳平台，培训未来的科学家，使他们能够充分利用所有基因组技术，更有效地解决社会紧迫的问题和问题。