SBIR Phase IB: Development and Characterization of Bio-inert UNCD films for Implantable Devices to Eliminate Blood Clotting

SBIR IB 期：用于消除血液凝固的植入装置的生物惰性 UNCD 薄膜的开发和表征

• 批准号: 1003516
• 负责人: John Carlisle
• 金额: $ 4.96万
• 依托单位: ADVANCED DIAMOND TECHNOLOGIES
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1003516&HistoricalAwards=false
• 关键词: SBIR; Phase; IB; Development; Characterization

This Small Business Innovation Research (SBIR) Phase I project will investigate UNCD®, a nanocrystalline from of smooth, thin diamond, as an anti-thrombotic coating for implantable medical devices. One of the largest problem with implantable circulatory assist devices such as artificial hearts and vascular assist devices (VADs) is the need to treat patients with anticoagulants to avoid blood clots within the devices and to avoid heart attack, stroke, and death that may occur if the anticoagulation dosage is not right. Previous work on diamond and diamond-like carbon (DLC) has demonstrated reduced interactivity between the coating and human blood clotting factors. The use of UNCD however, with its overall biochemical and electrochemical inertness, extreme durability to wear, and very low surface roughness, will extend the advantages previously demonstrated with other carbon materials. The broader impacts of this research are the potential reduction or elimination of anticoagulants for patients with implanted medical devices, making a much larger patient population eligible for advanced devices such as heart pumps, and enabling the use of these devices for new applications. UNCD coatings on the blood contacting surfaces of these and similar devices has the potential to eliminate the need for anticoagulation or to reduce it to so low a dose that the risk of fatal bleeding can be eliminated. The reduction in prescription costs alone could pay for this investment many times over. Fundamental work will also shed light on the effects of dynamic blood flow, variations in surface chemistry and morphology on the thrombus/clot formation.

这项小型企业创新研究（SBIR）I阶段项目将研究UNCD®，这是一种来自光滑，薄钻石的纳米晶体，作为一种可植入的医疗设备的抗血栓涂层。植入电路辅助设备（例如人造心脏和血管辅助设备（VAD））的最大问题之一是需要治疗抗凝剂患者以避免设备内的血凝块，并避免如果抗凝剂量不正确，则需要避免心脏病发作，中风和死亡。先前关于钻石和钻石样碳（DLC）的工作表明，涂料和人类血液凝结因子之间的相互作用降低了。然而，UNCD的使用，其整体生化和电化学惰性，极端的磨损性以及非常低的表面粗糙度将扩大先前用其他碳材料证明的优势。这项研究的更广泛的影响是，植入医疗设备的患者的潜在减少或消除了抗凝剂，这使得有资格使用高级设备（例如心脏泵）的患者人群，并允许将这些设备用于新应用。这些和类似设备的血液接触表面上的UNCD涂层有可能消除抗凝需求或将其降低至如此低的剂量，以至于可以消除致命出血的风险。仅处方成本的降低就可以多次为这项投资支付。基本工作还将阐明动态血流的影响，表面化学的变化和形态对血栓/凝块形成的影响。