CAREER: Inorganic Nanoparticles with Biological Properties: Preparation, Characterization and Sensing Applications

职业：具有生物特性的无机纳米颗粒：制备、表征和传感应用

• 批准号: 0954919
• 负责人: Emanuela Andreescu
• 金额: $ 49.63万
• 依托单位: Clarkson University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2016-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0954919&HistoricalAwards=false
• 关键词: CAREER; Inorganic; Nanoparticles; Biological; Properties

ID: MPS/DMR/BMAT(7623) 0954919 PI: Andreescu, Emanuela ORG: Clarkson UniversityTitle: CAREER: Inorganic Nanoparticles with Biological Properties: Preparation, Characterization and Sensing ApplicationsINTELLECTUAL MERIT: The objective of this career development plan is to develop and study a new class of inorganic biomimetic materials, with focus on ceria based metal oxides. The plan is designed to advance understanding of the mechanism that governs their biological properties in relation to their physicochemical properties and to derive structure-activity relations for the purpose of rational design of novel sensing approaches based on these materials. The proposed research will provide key experimental data in a new and unique area of biomaterials research, that of inorganic materials possessing interesting bio-mimetic properties and oxygen storage ability, and of their applications in sensing. Specifically, this will be the first investigation of the enzyme-like activity of ceria based metal oxides nanoparticles (NPs) in relation to their physicochemical and structural characteristics. Research will involve: (1) optimizing and controlling surface reactivity through tailored synthesis and systematic modifications of the NPs surface, (2) identifying key parameters that regulate NPs reactivity and using these properties to control their biological activity, (3) testing their ?enzyme-like? activity and (4) sensing applications that will take advantage of their special biomimetic properties, and their oxygen storage capacity.BROADER IMPACTS: This research introduces a unique concept in the biomaterials research arena, that of inorganic materials mimicking traditional biological catalysts and possessing oxygen storage/release capabilities for advanced biomedical and sensing applications. The fundamental knowledge gained from these studies will enable rational design of a new generation of bio-mimetic materials and devices with unprecedented performance in terms of stability, robustness, and low oxygen dependency. In addition to biomaterials and biosensors, this research will also impact a variety of other fields where these materials could find useful applications (e.g. biomedicine as therapeutic drugs to inactivate reactive oxygen species, biotechnology as catalysts that require operation at extreme conditions). The project will have a major impact on course development, student training, recruitment and mentoring. A new upper level undergraduate-graduate course and inquiry-based laboratory modules will be developed to provide interdisciplinary education of Clarkson students. Learning modules and instructor support materials for hands-on experiments will be created for introduction to local high schools through the planned outreach activities. Graduates and undergraduates will collaborate to prepare high school and general chemistry versions of the proposed experiments in consultation with faculty and high school teachers and students. A pilot program for enhancing retention rates of entering freshmen will be instituted. The project will contribute to the efforts of the Chemistry Department to strengthen the biomolecular science program and increase and retain the numbers of science majors at Clarkson. The proposed inquiry-based laboratory modules will enhance accessibility to modern scientific technologies and provide materials that are transferable to other institutions and to a larger number of students including local high schools and community colleges. Through this program, underrepresented minority students, recruited through on-going programs and established collaborations of the PI, will be provided with an opportunity to conduct independent research.

ID：MPS/DMR/BMAT（7623）0954919 PI：Andreescu，Emanuela org：Clarkson Universitytitle：职业：具有生物学特性的无机纳米颗粒：制备，表征和感应的应用程序，基于这一职业发展的材料的目标：氧化物。该计划旨在促进对控制其生物化学特性的生物学特性的机制的理解，并得出结构活性关系，目的是基于这些材料的新型感测方法的理性设计。 拟议的研究将在生物材料研究的新独特领域，具有有趣的生物模拟特性和氧气储存能力的无机材料及其在感知中的应用中提供关键的实验数据。具体而言，这将是对二氧化物金属氧化物纳米颗粒（NP）的酶样活性的首次研究。研究将涉及：（1）通过定制的合成和NPS表面的系统修饰来优化和控制表面反应性，（2）识别调节NPS反应性并使用这些特性来控制其生物学活性的关键参数，（3）测试其酶样？活动和（4）将利用其特殊仿生特性的传感应用及其氧气储存能力。Boader的影响：这项研究引入了生物材料研究领域中的独特概念，模仿传统生物催化剂的无机材料，该材料具有传统的生物催化剂，并具有氧气存储/释放能力，可用于先进的生物素质和感知应用。从这些研究中获得的基本知识将使新一代的生物模拟材料和设备的合理设计在稳定性，鲁棒性和低氧依赖性方面具有前所未有的性能。除生物材料和生物传感器外，这项研究还将影响这些材料可以找到有用的应用的许多其他领域（例如，生物医学作为治疗药物，以灭活活性氧，生物技术作为在极端条件下需要运行的催化剂）。该项目将对课程发展，学生培训，招聘和指导产生重大影响。将开发一个新的上层本科生课程和基于询问的实验室模块，以提供克拉克森学生的跨学科教育。 将通过计划的外展活动为当地高中创建学习模块和教师支持材料，以介绍当地高中。毕业生和本科生将在与教职员工，高中教师和学生协商下合作准备拟议实验的高中和一般化学版本。将制定一项用于提高进入新生保留率的试点计划。该项目将有助于化学系的努力加强生物分子科学计划，并增加和保留克拉克森的科学专业人数。拟议的基于查询的实验室模块将增强对现代科学技术的可及性，并提供可转让给其他机构以及包括当地高中和社区学院在内的更多学生的材料。通过这项计划，将提供通过正在进行的计划招募并建立PI合作的少数民族学生的机会，并将提供独立研究的机会。