Investigations of the Size Effects on the Relaxation Rates of Polymer Coated Magnetic Nanoparticles for Hyperthermia

热疗用聚合物包覆磁性纳米颗粒弛豫率的尺寸效应研究

• 批准号: 0907167
• 负责人: Olin Mefford
• 金额: $ 29万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0907167&HistoricalAwards=false
• 关键词: Investigations; Size; Effects; Relaxation; Rates

ID: MPS/DMR/BMAT(7623) 0907167 PI: Mefford, Olin T. ORG: Clemson UniversityTitle: Investigations of the Size Effects on the Relaxation Rates of Polymer Coated Magnetic Nanoparticles for HyperthermiaINTELLECTUAL MERIT: The PI proposes to investigate the factors affecting magnetic hyperthermia in nano-scale polymer-coated magnetic oxide particles. Magnetic particles acquire thermal energy from applied electromagnetic radiation and if the particles can be targeted into cancerous cells these cells can be killed by heating them to moderate temperatures ( 40 °C) without harming the surrounding tissue. The rate of response of the particle-coating complex to an alternating electromagnetic (EM) field is related to its relaxation time, and the materials issues that govern this behavior are not fully understood. A major objective of the proposed research is the acquisition of a fundamental understanding of the relaxation mechanisms. The sizes of the magnetic core and polymeric stabilizing layer can both greatly influence the response of these materials to EM radiation. However, it is not well understood how the ratio of these two dimensions affects the thermal response to different magnetic fields and field frequencies. The PI proposes to develop model systems of coated and non-coated magnetic nanoparticles, measure how the sizes and size distributions of the core particles and the polymer/particle complexes affect the relaxation rates of the suspensions, measure the heating rates of different nanoparticle systems in solvent systems similar to those found in the human body and tailor the sizes of the magnetic core and the polymer brushes to optimize heating at specific heating frequencies and fields.BROADER IMPACTS: The topic of the proposal is of current interest, and there will be abundant opportunities for dissemination of results in conferences and in publications. The work provides a foundation for pharmaceutical companies to develop new nanoparticle-based therapies and imaging agents. A successful outcome will impact not only hyperthermia research but also magnetism, polymer chemistry, and colloid chemistry. This project is at the intersection of physics, chemistry, and biology and thus provides a platform for interdisciplinary training of students. In addition to the graduate students on the project, it will provide opportunities for two undergraduate research students. The development of good writing and oral presentation skills is critical for the development of future scientists and engineers. One of the goals of the project is to provide opportunities for the students to present their work at national and international meetings. The PI will participate in the J. E. Sirrine Summer Program that exposes South Carolina high-school students to materials science research. It is expected that his group will mentor two of these students. One of the goals of this work is to develop teaching tools for Clemson representatives to travel across the Southeast to educate high school students on research in bionanomaterials.

ID: MPS/DMR/BMAT(7623) 0907167 PI: Mefford, Olin T. ORG: Clemson UniversityTitle: Investigations of the Size Effects on the Relaxation Rates of Polymer Coated Magnetic Nanoparticles for HyperthermiaINTELLECTUAL MERIT: The PI proposals to investigate the factors affecting magnetic hyperthermia in nano-scale polymer-coated magnetic oxide particles.磁性颗粒从应用的电子辐射中获取热能，如果可以将颗粒靶向取消细胞，则可以通过将它们加热到中等温度（40°C）而不会损害周围的组织来杀死这些细胞。粒子涂层复合物对替代电磁（EM）场的响应速率与其放松时间有关，并且尚未完全了解控制这种行为的材料问题。拟议研究的主要目的是获得对放松机制的基本理解。磁芯和聚合物稳定层的尺寸都可以很大程度上影响这些材料对EM辐射的响应。但是，尚不清楚这两个维度的比率如何影响对不同磁场和场频率的热响应。 PI提出开发涂层和非涂层磁性纳米粒子模型系统的建议，衡量核心颗粒的尺寸和大小分布如何影响悬浮液的松弛速率，测量与在人体和磁心量的特定尺寸相似的纳米粒子系统中不同纳米颗粒系统的加热速率，并衡量磁性系统中的磁性系统，并衡量磁性量的磁性和量化尺寸，并量身定制了磁盘的尺寸，并量身定制了磁性尺寸。 Fields.BOADER的影响：该提案的主题是当前感兴趣的，并且在会议和出版物中将有很多机会传播结果。这项工作为制药公司开发新的基于纳米颗粒的疗法和成像剂的基础为基础。成功的结果不仅会影响热疗研究，还会影响磁性，聚合物化学和胶体化学。该项目位于物理，化学和生物学的交集，因此为学生提供了跨学科培训的平台。除了该项目的研究生外，它将为两名本科研究专业的学生提供机会。良好的写作和口头表现技巧的发展对于未来科学家和工程师的发展至关重要。该项目的目标之一是为学生提供在国家和国际会议上介绍其工作的机会。 PI将参加J. E. Sirrine夏季计划，该计划将南卡罗来纳州的高中生暴露于材料科学研究中。预计他的小组将指导其中两个学生。这项工作的目标之一是为克莱姆森（Clemson）开发教学工具，代表在东南部旅行，以教育高中生关于BiionAnomamatials的研究。