Harnessing PET to Study the In Vivo Fate and Health Effects of Micro- and Nanoplastics

利用 PET 研究微塑料和纳米塑料的体内命运和健康影响

基本信息

批准号：
10890903
负责人：
Outi Maria Keinaenen
金额：
$ 24.9万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10890903
关键词：
Air Animals Autoradiography Behavior Biodistribution Biological Biological Markers Biological Models Cardiovascular system Chelating Agents Chronic Communication Consumption Data Decision Making Deposition Disease Dose Employment Environment Environmental Pollutants Environmental Pollution Evaluation Exposure to Fetal Development Food Foundations Fresh Water Future Goals Grant Health Histology Human Image Imaging Techniques Immunohistochemistry In Vitro Inflammation Inflammatory Inflammatory Response Ingestion Inhalation Interdisciplinary Study Intestines Investigation Iodine Radioisotopes Label Laboratories Light Liquid substance Lung Mammals Mentors Methods Microscopic Modeling Mus Musculoskeletal System Nervous System Nulliparity Oral Outcome Particle Size Pharmacology Study Pharmacology and Toxicology Phase Physiological Placenta Plastics Polystyrenes Positron-Emission Tomography Postdoctoral Fellow Pregnancy Process Proliferating Radiochemistry Radiolabeled Radiopharmaceuticals Research Resources Role Route Seawater Sewage Shapes Site Soil Stomach Structure Surface Techniques Time Tissues Toxic effect Tracer Visualization Work absorption bioaccumulation career career development collaborative environment college drinking water experimental study exposed human population exposure route imaging approach in vivo in vivo evaluation innovation meter molecular imaging nuclear imaging particle pollutant pre-clinical pregnant programs radiotracer remediation research and development sialic acid binding Ig-like lectin skills tool trend uptake

项目摘要

ABSTRACT CANDIDATE: The candidate is a postdoctoral fellow in the laboratory of Dr. Zeglis at Hunter College of CUNY. Her proposed research will provide a strong foundation for independent research career following the K99 phase of this grant. Her long-term career goal is to establish a robust program in environmental pollution research utilizing molecular imaging. To achieve this, she has developed a career plan that will (1) broaden her technical and scientific skills (2) strengthen her presentation and communication skills, and cultivate her professional relationships, (3) enrich her mentoring skills, and (4) prepare her for the transition to independence. RESEARCH: The proliferation of micro- and nanoplastics in the environment is increasing at an alarming rate. Micro- and nanoplastics have been found to be persistent and ubiquitous pollutants in a variety of environments, including sea water, fresh water, soil, sewage, and air. In light of this harrowing phenomenon, the evaluation of the possible health effects of microplastic (<5 mm) and nanoplastic (<100 nm) pollutants has emerged as an unmet scientific need. The over-arching goal of this investigation is to study the biodistribution and health effects of micro- and nanoplastics in mammals using a sensitive and quantitative molecular imaging technique: positron emission tomography (PET). The exquisite sensitivity of PET is major advantage of this strategy, as it will facilitate the non-invasive tracking of micro- and nanoplastics at environmentally relevant concentrations. The specific aims are: 1) To determine the bioaccumulation and bioretention of radioplastics in mice after pulmonary and oral exposure, 2) To quantify the bioaccumulation and bioretention of radioplastics in pregnant mice after oral and pulmonary exposure, and 3) To quantify the pro-inflammatory effects of micro- and nanoplastic exposure via non-invasive approaches. ENVIRONMENT: Hunter College is known for its highly collaborative environment to facilitate interdisciplinary research efforts such as those proposed in this application. The candidate is mentored by Dr. Zeglis, a recognized inorganic radiochemist with groundbreaking work in preclinical investigations of radiopharmaceuticals. In addition, she is co-mentored by Dr. Stapleton, an environmental toxicologist who has done pioneering and innovative contributions to the plastic research. Hunter College provides a rich set of collaborative, technical and scientific resources to execute the research and career development proposed here.

抽象的候选人：候选人是CUNY亨特学院Zeglis博士实验室的博士后研究员。她提出的研究将为K99阶段之后的独立研究职业提供坚实的基础这笔赠款。她的长期职业目标是在环境污染研究中建立强大的计划利用分子成像。为了实现这一目标，她制定了一项职业计划，该计划将（1）扩大她的技术科学技能（2）增强了她的演讲和沟通技巧，并培养她的专业人士人际关系，（3）丰富了她的指导技能，（4）为她的过渡做好准备。研究：环境中微塑料和纳米塑料的增殖正在以惊人的速度增加。在各种环境中，已经发现微塑料和纳米塑料是持久和无处不在的污染物，包括海水，淡水，土壤，污水和空气。鉴于这种令人痛苦的现象，评估微型塑料（<5 mm）和纳米塑料（<100 nm）污染物的可能影响已成为一种未满足的科学需求。这项调查的整个目标是研究生物分布和健康效应使用敏感和定量的分子成像技术的哺乳动物中的微塑料和纳米塑料的排放断层扫描（PET）。宠物的精致敏感性是该策略的主要优势，因为它将在环境相关的浓度下促进微塑料和纳米塑料的非侵入性跟踪。这具体目的是：1）确定肺后小鼠放射性塑料的生物累积和生物衰落和口服暴露，2）量化孕妇在口服和肺暴露，以及3）量化微型和纳米塑性暴露的促炎作用通过非侵入性方法。环境：亨特学院以其高度协作的环境而闻名，以促进跨学科诸如本申请中提出的研究工作。候选人由Zeglis博士指导公认的无机放光化学家在临床前研究中进行了突破性的工作放射性药物。此外，她还由Stapleton博士（一位环境毒理学家）授予为塑料研究做了开拓和创新的贡献。亨特学院提供了一组协作，技术和科学资源，以执行此处提出的研究和职业发展。