Collaborative Research: An Arabidopsis Polymorphism Database

合作研究：拟南芥多态性数据库

• 批准号: 0723860
• 负责人: Brandon Gaut
• 金额: $ 48.63万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0723860&HistoricalAwards=false
• 关键词: Collaborative; Research; Arabidopsis; Polymorphism; Database

Abstract This project will to generate a community resource for Arabidopsis genetics by integrating several new data sets with the existing A. thaliana genome sequence and those of two closely related species, A. lyrata and Capsella rubella. These data will make it possible to answer fundamental questions about the evolution of A. thaliana, and will facilitate the interpretation of the existing genome sequence. It is analogous to similar efforts to understand human variation and evolution by integrating vast amounts of human polymorphism data with genome sequences from closely related primates like chimpanzee and orangutan. This project will provide a tool for making sense of genetic variation. Understanding how genotypic variation translates into phenotypic variation and how it is structured in populations is fundamental to our understanding of evolution, and has enormous practical implications for human health as well as for plant and animal breeding. The project will also provide training opportunities in bioinformatics and computational biology for multiple students at different levels, areas where there is a nationally recognized shortage of biology students with the requisite quantitative skills.

摘要 该项目将通过将几个新数据集与现有拟南芥基因组序列以及两个密切相关的物种琴叶拟南芥和红荠菜的基因组序列相整合，为拟南芥遗传学生成社区资源。这些数据将有可能回答有关拟南芥进化的基本问题，并将有助于解释现有的基因组序列。这类似于通过将大量人类多态性数据与黑猩猩和猩猩等密切相关的灵长类动物的基因组序列整合来了解人类变异和进化的类似努力。该项目将提供一种理解遗传变异的工具。了解基因型变异如何转化为表型变异以及它在群体中的结构是我们理解进化的基础，并且对人类健康以及植物和动物育种具有巨大的实际意义。该项目还将为不同级别的多名学生提供生物信息学和计算生物学方面的培训机会，这些领域是全国公认缺乏具备必要定量技能的生物学学生的领域。