Acquisition of a 400 MHz Spectrometer and Upgrade of Departmental NMR Facility

购置 400 兆赫光谱仪及升级部门核磁共振设施

• 批准号: 0521698
• 负责人: Douglas Grotjahn
• 金额: --
• 依托单位: San Diego State University Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0521698&HistoricalAwards=false
• 关键词: Acquisition; 400; MHz; Spectrometer; Upgrade

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at San Diego State University will acquire a 400 MHz nuclear magnetic resonance (NMR) Spectrometer. This equipment will enable researchers to carry out studies in the following areas: (1) Proton Transfer and Hydrogen Bonding in Organometallic Structure and Catalysis, (2) New Organocopper Reactions: Mechanisms and Methodology, (3) New Scorpionate Ligands for Inorganic Chemistry and The Role of Boron and Iron in Harmful Algal Blooms, (4) High Resolution NMR-Derived Conformations of Molecules of Biochemical Importance, (5) Combined Computational and Experimental Approaches for the Design of Protein-Protein Interactions, and (6) Interactions between Holliday Junction-Binding Molecules and Target DNA. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact a number of areas, especially biochemistry.

在主要研究仪器 (MRI) 计划的支持下，圣地亚哥州立大学化学系将购买一台 400 MHz 核磁共振 (NMR) 波谱仪。该设备将使研究人员能够开展以下领域的研究：（1）有机金属结构和催化中的质子转移和氢键，（2）新有机铜反应：机理和方法，（3）用于无机化学和催化的新蝎形配体硼和铁在有害藻华中的作用，(4) 具有生化重要性的分子的高分辨率 NMR 构象， (5) 蛋白质-蛋白质相互作用设计的计算和实验相结合的方法，以及 (6) 霍利迪连接结合分子与靶 DNA 之间的相互作用。 核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。这些核磁共振研究的结果将对许多领域产生影响，尤其是生物化学。