MRI: Acquisition of 400 MHz NMR Spectrometer for Chemistry Research

MRI：购买 400 MHz NMR 波谱仪用于化学研究

• 批准号: 2216273
• 负责人: Thomas Mobley
• 金额: $ 40万
• 依托单位: Grinnell College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216273&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; NMR

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs, and the Established Program to Stimulate Competitive Research. Grinnell College is acquiring an upgraded console for a 400 MHz nuclear magnetic resonance (NMR) spectrometer with a diffusion probe to support the research of Professor Andrew Mobley and colleagues Erick Leggans, Leslie Lyons, Molly MacInnes, and Stephen Sieck. This instrument facilitates research in the areas of organic chemistry, organometallic chemistry, natural products, and material science. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments at Grinnell College as well as provides accessibility for use at nearby institutions. The instrument also enables the research groups to work actively to recruit students from a diverse background and broaden the representation of minoritized groups in the sciences.The award of the NMR spectrometer is aimed at enhancing the research and education at all levels, especially in areas such as organic chemistry, organometallic chemistry, natural products, and material science. The instrument impacts research focused on advancing the understanding of heterobimetallic complexes and ion transport in electrolytes and graphitic networks. Specifically, the instrument will be used in a wide spectrum of projects such as: 1) heteronuclear NOE and NMR-relaxation studies of Sn hydride complexes of W and Pt, 2) detailed variable temperature structural studies of the conformational behavior of the natural product lugdunin, 3) structural determination of the interaction between solvent and metal ions in electrolytes for Li-ion and Na batteries, 4) self-diffusion studies of Li, Na, and Ln ions in graphitic suspensions, and 5) J-coupling studies to determine the configuration and solution state conformation of novel chalcones. The research projects to be enabled by the 400MHz NMR spectrometer could lead to impacts in the fields such as energy storage and biotechnology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目以及促进竞争性研究的既定项目共同支持。 格林内尔学院正在购买一台带扩散探针的 400 MHz 核磁共振 (NMR) 波谱仪升级控制台，以支持 Andrew Mobley 教授及其同事 Erick Leggans、Leslie Lyons、Molly MacInnes 和 Stephen Sieck 的研究。 该仪器促进了有机化学、有机金属化学、天然产物和材料科学领域的研究。 一般来说，核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。该工具增强了格林内尔学院许多院系各级学生的教育、研究和教学工作，并为附近机构提供了使用便利。 该仪器还使研究小组能够积极招收来自不同背景的学生，并扩大少数群体在科学领域的代表性。核磁共振波谱仪的获奖旨在加强各级的研究和教育，特别是在以下领域如有机化学、有机金属化学、天然产物和材料科学。该仪器影响的研究重点是增进对异双金属配合物以及电解质和石墨网络中离子传输的理解。具体来说，该仪器将用于广泛的项目，例如：1) W 和 Pt 的 Sn 氢化物配合物的异核 NOE 和 NMR 弛豫研究，2) 天然产物 lugdunin 构象行为的详细变温结构研究，3）锂离子和钠电池电解质中溶剂和金属离子之间相互作用的结构测定，4）石墨中Li、Na和Ln离子的自扩散研究悬浮液，以及 5) J-耦合研究以确定新型查尔酮的构型和溶液状态构象。由 400MHz 核磁共振波谱仪支持的研究项目可能会对能源存储和生物技术等领域产生影响。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。