Proton Transfer and Hydrogen Bonding in Organometallic Structure and Catalysis

有机金属结构和催化中的质子转移和氢键

• 批准号: 0415783
• 负责人: Douglas Grotjahn
• 金额: $ 37.8万
• 依托单位: San Diego State University Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0415783&HistoricalAwards=false
• 关键词: Proton; Transfer; Hydrogen; Bonding; Organometallic

This research program focuses on the design, synthesis, and study of bifunctional catalysts containing both Bronsted basic and organometallic (Lewis acidic) sites. Assisted by calculational studies, bifunctional ligands will be designed and synthesized. Following preparation and characterization of transition metal complexes of these ligands, these complexes will be explored in the catalysis of the anti-Markovnikov addition of hydroxylic compounds to alkynes and alkenes, hydration of nitriles, cyclization of alkynols and alkynylamides, addition of terminal alkynes to carbonyl compounds, and hydroamination of alkenes.With the support of the Organic and Macromolecular Chemistry Program, Professor Douglas B. Grotjahn, of the Department of Chemistry and Biochemistry at San Diego State University, is developing new catalysts designed to effect important chemical transformations through two-site interactions. Catalysis enables the efficient and environmentally sound synthesis of organic compounds. By utilizing design principles inspired by Nature's catalysts, the enzymes, Professor Grotjahn's studies promise both new mechanisms for the catalysis of reactions and the creation of catalysts able to effect completely new reactions.

该研究项目重点关注含有布朗斯台德碱性和有机金属（路易斯酸性）位点的双功能催化剂的设计、合成和研究。在计算研究的协助下，将设计和合成双功能配体。在这些配体的过渡金属配合物的制备和表征之后，将探索这些配合物在羟基化合物与炔烃和烯烃的反马尔可夫尼科夫加成、腈的水合、炔醇和炔酰胺的环化、末端炔烃与羰基的加成的催化中的应用。在有机和高分子化学项目的支持下，Douglas B.圣地亚哥州立大学化学与生物化学系的 Grotjahn 正在开发新型催化剂，旨在通过两个位点相互作用实现重要的化学转化。催化能够高效、环保地合成有机化合物。通过利用受大自然催化剂酶启发的设计原理，Grotjahn 教授的研究有望实现催化反应的新机制以及能够实现全新反应的催化剂的创造。