Proton Transfer and Hydrogen Bonding in Organometallic Structure and Catalysis

有机金属结构和催化中的质子转移和氢键

• 批准号: 0415783
• 负责人: Douglas Grotjahn
• 金额: $ 37.8万
• 依托单位: San Diego State University Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0415783&HistoricalAwards=false
• 关键词: Proton; Transfer; Hydrogen; Bonding; Organometallic

This research program focuses on the design, synthesis, and study of bifunctional catalysts containing both Bronsted basic and organometallic (Lewis acidic) sites. Assisted by calculational studies, bifunctional ligands will be designed and synthesized. Following preparation and characterization of transition metal complexes of these ligands, these complexes will be explored in the catalysis of the anti-Markovnikov addition of hydroxylic compounds to alkynes and alkenes, hydration of nitriles, cyclization of alkynols and alkynylamides, addition of terminal alkynes to carbonyl compounds, and hydroamination of alkenes.With the support of the Organic and Macromolecular Chemistry Program, Professor Douglas B. Grotjahn, of the Department of Chemistry and Biochemistry at San Diego State University, is developing new catalysts designed to effect important chemical transformations through two-site interactions. Catalysis enables the efficient and environmentally sound synthesis of organic compounds. By utilizing design principles inspired by Nature's catalysts, the enzymes, Professor Grotjahn's studies promise both new mechanisms for the catalysis of reactions and the creation of catalysts able to effect completely new reactions.

该研究计划的重点是包含Bronsted碱性和有机金属（Lewis Acidic）位点的双功能催化剂的设计，合成和研究。在计算研究的协助下，将设计和合成双功能配体。在这些配体的过渡金属复合物的制备和表征之后，将探索这些络合物在抗山摩托克尼科夫添加羟基化合物中添加到炔烃和烯烃中的抗菌酸化合物，水分的水合，环化酸性和酸性烯丙基的碱性烯烃，并添加了氧化烷基的烯烃，并构成了混合物，并构成了混合物，并构成了混合物，并构成了混合物，并构成了混合物，并构成了氧化碱的含量。在有机和大​​分子化学计划中，圣地亚哥州立大学化学和生物化学系的道格拉斯·B·格罗杰（Douglas B.催化使有机化合物的有效和环境合成。通过利用受自然催化剂启发的设计原理，酶，Grotjahn教授的研究有助于催化反应的新机制和能够实现全新反应的催化剂的创建。