RUI: Effect of Dietary Protein on Structure and Function of the Avian Nephron

RUI：膳食蛋白质对禽肾单位结构和功能的影响

• 批准号: 9982985
• 负责人: David Goldstein
• 金额: $ 18.3万
• 依托单位: Wright State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9982985&HistoricalAwards=false
• 关键词: RUI; Effect; Dietary; Protein; Structure

Many birds change during growth or seasonal cycles from eating diets low in protein, such as seeds, to diets high in protein, such as insects. In mammals, changing to a high protein diet induces a number of changes in the kidneys, including enlargement of the organs and changes in the production and composition of the urine. In humans, these changes are important contributors to the progression of renal failure, and there is concern about these consequences also associated with the current popularity of high protein/low carbohydrate dieting. Birds possess many of the same elements to their anatomy and physiology as are suggested to be involved in the mammalian response to eating protein; however, birds lack others of these elements. Thus, birds can serve as a natural model for testing theories about the links between diet and consequences for the kidneys. In the proposed studies, Dr. Goldstein will explore the ways in which diet influences the responsiveness of the kidneys to hormones released in response to feeding. He will do so by raising bobwhite quail on high-vs.-low protein diets, and then exploring organ structure, kidney function, and the biochemical responses of kidney cells and tissues. These studies will help to define the physiology of a bird (the bobwhite quail) that is valuable both as a domestic and a wildlife species. They will also clarify assumptions and hypotheses proposed for mammalian kidneys, and thereby help to elucidate the link between dietary protein and the progression of renal failure.

在生长或季节性周期中，许多鸟类从蛋白质（例如种子）中的饮食饮食（例如蛋白质（例如昆虫））变化。 在哺乳动物中，转变为高蛋白质饮食会引起肾脏的许多变化，包括器官的扩大以及尿液的产生和组成的变化。 在人类中，这些变化是导致肾衰竭进展的重要因素，并且对这些后果的关注也与当前高蛋白/低碳水化合物节食的流行有关。 鸟类具有与哺乳动物对进食蛋白的反应有关的解剖学和生理学的许多相同元素。但是，鸟类缺乏这些元素。 因此，鸟类可以用作自然模型，用于测试有关饮食与肾脏后果之间联系的理论。 在拟议的研究中，戈德斯坦博士将探讨饮食影​​响肾脏对响应喂养释放的激素的反应性的方式。 他将通过在高VSS的高蛋白饮食上提高鲍勃白鹌鹑，然后探索器官结构，肾功能以及肾细胞和组织的生化反应。 这些研究将有助于定义鸟类的生理学（鲍尔鹌鹑），这些生理学既是一种家庭和野生动植物物种都有价值。 他们还将阐明针对哺乳动物肾脏提出的假设和假设，从而有助于阐明饮食蛋白与肾衰竭进展之间的联系。