Quantifying Epistasis for Fitness in the Native Legume, Chamaecrista Fasciculata

量化原生豆科植物 Chamaecrista Fasciculata 的上位性

基本信息

批准号：
9815780
负责人：
Charles Fenster
金额：
$ 24.17万
依托单位：
University of Maryland, College Park
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
1999
资助国家：
美国
起止时间：
1999-02-01 至 2004-01-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9815780&HistoricalAwards=false
关键词：
Quantifying Epistasis Fitness Native Legume

项目摘要

9815780Fenster & Zimmer This research concerns the type of gene action responsible for genetic differences among populations of Chamaecrista fasciculata. Genes may act independently of one another so that genetic divergence may simply reflect the accumulated effects of selection acting on single genes. However, important differences among organisms may reflect selection on combinations of genes implying that gene interaction or epistasis is important. The type of gene action can be determined by following the survivorship and reproduction of progeny derived from crosses between populations. If populations are adapted to their environment because selection has acted on combinations of genes, then mixing genes from different populations will result in a disruption of favorable gene interactions and decreased survivorship and reproduction in the hybrid progeny. This study will use traditional biometrical techniques along with molecular analyses to quantify the nature of gene action responsible for adaptation of a population to its environment. This project has important implications for evolution, crop and animal breeding, and conservation biology. If organisms are adapted to their environment because of interactions among genes, then our models of evolution will need to be more complex. Detection of important gene interaction will provide us with a microevolutionary equivalent of macroevolutionary processes such as speciation. Gene interactions imply that different breeding strategies than those presently employed may have greater efficacy for crop and animal improvement. Strategies for maintaining or preserving genetic diversity in endangered species will be influenced by whether gene interaction determines traits associated with survivorship and reproduction.

9815780fenster＆Zimmer这项研究涉及造成Chamaecrista fasciculata种群遗传差异的基因作用的类型。基因可以彼此独立起作用，因此遗传差异可以简单地反映出作用对单个基因的累积影响。然而，生物体之间的重要差异可能反映出基因组合的选择，这表明基因相互作用或上毒很重要。基因作用的类型可以通过遵循从人群之间的杂交中获得的生存和繁殖来确定。如果种群适应其环境，因为选择对基因的组合作用，那么来自不同种群的基因的混合将导致有利的基因相互作用的破坏，并降低了混合后代的生存和生存和繁殖。这项研究将使用传统的生物识别技术以及分子分析来量化负责将人群适应其环境适应的基因作用的性质。该项目对进化，农作物和动物育种以及保护生物学具有重要意义。如果由于基因之间的相互作用而适应了生物体，那么我们的进化模型将需要变得更加复杂。重要的基因相互作用的检测将为我们提供相当于宏观进化过程（例如物种形成）的微观进化。基因相互作用意味着与目前使用的育种策略不同，可能对作物和动物改善具有更大的功效。濒危物种中维持或保存遗传多样性的策略将受到基因相互作用是否决定与生存和繁殖有关的特征。