Development of a Catalytic, Asymmetric {2+2} Cycloaddition for the Synthesis of 2-Oxetanones

用于合成 2-氧杂环丁酮的催化不对称 {2 2} 环加成反应的开发

• 批准号: 9510566
• 负责人: Daniel Romo
• 金额: $ 1.8万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9510566&HistoricalAwards=false
• 关键词: Development; Catalytic; Asymmetric; 2+2; Cycloaddition

This RPG in the Organic Synthesis Program to Professor Romo of Texas A&M University will be used to elaborate the chiral catalysis of 2 + 2 cycloadditions for the synthesis of 2-oxetanones. These compounds which are better known as beta lactones are important moieties in many physiologically active chemical compounds. Moreover, these types of monomers are used in polymerization reactions and in organic synthetic strategies. The control of catalytic processes in such a way as to yield chiral products is an important goal. This proposal has this goal and appears to be an excellent opportunity to find new ways of synthesizing physiologically active compounds. These results will be useful in the medicinal chemistry and polymer fields.

德克萨斯州A＆M大学罗莫教授的有机合成计划中的这一RPG将用于详细说明2 + 2个环加成的手性催化，以合成2-氧化烷酮。在许多生理活性化合物中，这些更称为β内酯的化合物是重要的部分。此外，这些类型的单体用于聚合反应和有机合成策略。 对催化过程的控制以产生手性产品是一个重要目标。该建议具有这个目标，似乎是找到合成生理活性化合物的新方法的绝佳机会。这些结果将在药物化学和聚合物场中有用。