Novel Asymmetric Routes to 2-Oxetanones and Their Application

2-氧杂环丁酮的新型不对称路线及其应用

• 批准号: 0416260
• 负责人: Daniel Romo
• 金额: $ 39万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0416260&HistoricalAwards=false
• 关键词: Novel; Asymmetric; Routes; Oxetanones; Their

The focus of this research involves the use of beta lactones in synthesis. Several applications of the intramolecular nucleophile catalyzed aldol-lactonization (NCAL) process will be highlighted. The NCAL process merges catalytic, asymmetric beta-lactone synthesis with carbocycle and heterocycle synthesis. Target molecules will include spongiolactone, a marine metabolite, and belactosin, an antitumor, Streptomyces metabolite. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Daniel Romo in the Department of Chemistry at Texas A&M University. Dr. Romo will focus his work on developing concise, practical enantioselective routes to beta-lactones (2-oxetanones) involving nucleophilic catalysis and the application of these methods to natural and unnatural product synthesis. The research could have a broader impact on the pharmaceutical industry and the project will be an excellent arena for the training of undergraduate and graduate students, many of whom come from the underrepresented minority population in Texas.

这项研究的重点涉及在合成中使用β内酯。 分子内亲核试剂催化的醛醇 - 乳化剂（NCAL）过程的几种应用将被突出显示。 NCAL过程将催化性，不对称β-内乳转酮合成与碳循环和杂环合成。 靶分子将包括海绵下代谢产物和抗肿瘤，链霉菌代谢物的Belactosin。通过此奖项，有机和大分子化学计划正在支持德克萨斯农工大学化学系的丹尼尔·罗莫（Daniel Romo）博士的研究。 Romo博士将把他的工作集中在开发涉及亲核催化的β-内酯（2-氧化酮）的简洁，实用的对映选择性途径上，并将这些方法应用于天然和不自然产物合成。 这项研究可能会对制药行业产生更大的影响，该项目将是培训本科生和研究生的绝佳舞台，其中许多人来自德克萨斯州代表性不足的少数群体。