Postdoctoral Fellowship: MPS-Ascend: Development of Catalytic, Asymmetric Ritter-Type Reactions of Racemic Precursors

博士后奖学金：MPS-Ascend：外消旋前体催化、不对称 Ritter 型反应的开发

• 批准号: 2316528
• 负责人: Andre Sanchez
• 金额: $ 30万
• 依托单位: Sanchez, Andre
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2316528&HistoricalAwards=false
• 关键词: Postdoctoral; Fellowship; MPS; Ascend; Development

Andre Sanchez is awarded an NSF Mathematical and Physical Sciences Ascending Postdoctoral Research Fellowship (NSF MPS-Ascend) to conduct a program of research and activities related to broaden participation by groups underrepresented in STEM (science, technology, engineering and mathematics). This fellowship to Dr. Sanchez supports the research project entitled “MPS-Ascend: Development of Catalytic, Asymmetric Ritter-Type Reactions of Racemic Precursors” under the mentorship of a sponsoring scientist. The host institution for the fellowship is Harvard University, and the sponsoring scientist is Dr. Eric Jacobsen. The proposal aims at the development of catalytic, asymmetric Ritter-type reactions from readily available racemic precursors using hydrogen-bond donor (HBD) catalysis to provide access to value-added chiral materials for small molecule-based drug discovery. The research plan outlines specific tactics that will enable the desired transformations through identification of a suitable HBD catalyst framework, capitalizing on a synergistic network of non-covalent interactions. A combination of mechanistic and computational investigations has the potential to provide insight into the critical non-covalent interactions and catalyst features necessary for enantioinduction. Scientific broader impacts include applications to drug discovery and development of new therapeutic technologies.The proposed project will serve as a teaching platform for the mentoring of high school, undergraduate, and graduate students from underrepresented minority groups. The PI will serve as a committee member on departmental and campus-wide diversity initiatives. The PI will participate in professional networking and conference opportunities aimed at building an inclusive community and diversifying the professoriate.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

安德烈·桑切斯（Andre Sanchez）被授予NSF数学和物理科学的上升博士后研究奖学金（NSF MPS-ASCEND），以开展与STEM（科学，技术，工程和数学）中代表性不足的团体扩大参与的研究和活动计划。在赞助科学家的心态下，桑切斯博士的这一奖学金支持了题为“ MPS-ASCEND：催化，不对称Ritter-type反应的催化，不对称Ritter-type反应”的研究项目。奖学金的主办机构是哈佛大学，赞助科学家是埃里克·雅各布森（Eric Jacobsen）博士。该提案旨在利用氢键供体（HBD）催化的催化，不对称的Ritter-Ritter型反应，以提供基于小分子的药物发现的增值性手性材料。该研究计划概述了特定策略，这些策略将通过识别合适的HBD催化剂框架来实现所需的转换，并在非共价相互作用的协同网络上利用。机械和计算调查的结合可以洞悉启用诱导所必需的关键非共价相互作用和催化剂特征。科学广播公司的影响包括对新治疗技术的药物发现和开发的应用。拟议的项目将作为高中，本科生和来自代表性不足少数群体的高中，本科生和研究生的教学平台。 PI将担任部门和校园范围内多元化计划的委员会成员。 PI将参加旨在建立包容性社区并使利润多样化的专业网络和会议机会。该奖项反映了NSF的法定任务，并通过使用基金会的知识分子优点和更广泛的影响评估标准来评估值得支持。