New Methods for Synthesis of Complex Chemicals

复杂化学品合成的新方法

• 批准号: 9412266
• 负责人: Larry Overman
• 金额: $ 51.62万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9412266&HistoricalAwards=false
• 关键词: New; Methods; Synthesis; Complex; Chemicals

9412266 Overman The focus of this research will be on the synthesis of stereochemically complex oxygen and nitrogen heterocycles by new cyclization methods and on the development of a general method for asymmetric catalysis of 3,3 -sigmatropic rearrangements. Five marine natural products, ptilomycalin A, crambescidin 800, isocrambescidin 800, manzamine A and (E)-pinnatifidenyne are the specific synthetic targets. %%% With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Larry E. Overman of the Department of Chemistry at the University of California, Irvine. Professor Overman will focus his work on the development of economical methods for the synthesis of complex organic molecules. The approach is expected to impact the discovery, development and production components of the pharmaceutical, agricultural and materials industries. ***

9412266这项研究的重点将是通过新的环化方法的立体化学复杂氧和氮杂环的合成，以及开发3,3-含量重排的不对称催化的一般方法。 五种海洋天然产物，Pittilomycalin A，Crambescidin 800，Isocrambescidin 800，Manzamine A和（E）-Pinnatifidenyne是特定的合成靶标。 合成有机计划凭借这一续签奖，支持加利福尼亚大学欧文分校化学系的Larry E. Overman博士的研究。 Overman教授将把他的工作集中在开发复杂有机分子的经济方法上。 预计该方法将影响制药，农业和材料行业的发现，开发和生产组成部分。 ***