New Reactions for Organic Synthesis

有机合成新反应

• 批准号: 9003812
• 负责人: Larry Overman
• 金额: $ 42.43万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9003812&HistoricalAwards=false
• 关键词: New; Reactions; Organic; Synthesis

This research is being funded by the Organic Synthesis Program. Dr. Overman will continue his development of new ring forming reactions, particularly focussing on the medium ring range. This will provide some of the new tools required by the increasingly complex demands of agriculture and industry. The studies for the project focus in two areas: (1) Developing new cyclization reactions for forming medium rings. Of all types of rings (small, common, medium and large) existing methods are least satisfactory for preparing medium rings. (2) Developing electrophilic cyclization reactions that are promoted by nucleophiles. Reactions of this type were recently discovered and hold exciting promise for greatly expanding the utility of simple alkynes in chemical synthesis.

这项研究是由有机合成计划资助的。 Overman博士将继续发展新的戒指反应，尤其是专注于中环范围。 这将为农业和工业的日益复杂的需求提供一些新工具。 该项目的研究重点在两个领域：（1）为形成中环的新环化反应开发新的环化反应。 在所有类型的环（小，常见，中和大）中，现有方法对于制备中环是最不令人满意的。 （2）发展由亲核试剂促进的亲电环化反应。 最近发现了这种类型的反应，并具有令人兴奋的希望，可以极大地扩展简单炔烃在化学合成中的实用性。